polyploid giant cancer cellsstemnesstherapeutic resistanceCancer led to the deaths of more than 9 million people worldwide in 2018, and most of these deaths were due to metastatic tumor burden. While in most cases, we still do not know why cancer is lethal, we know that a total tumor ...
Increased unique giant cancer cells housing complete nuclear localization of YAP were observed in SMG. This study highlights the role of microgravity in regulating stemness in CSC and importance of physical factors in determining the same.doi:10.1038/s41598-019-47116-5Raj Pranap Arun...
Therapeutic resistance in cancer significantly contributes to mortality, with many patients eventually experiencing recurrence after initial treatment responses. Recent studies have identified therapy-resistant large polyploid cancer cells in patient tissues, particularly in late-stage prostate cancer, linking the...
Polyploid giant cancer cells (PGCCs) are a unique subpopulation of grossly hyperdiploid cancer cells that differ from the bulk of dominantly aneuploid tumor cells in their morphology, tumorigenic ability, radio-resistance, and chemo-resistance. The vast majority of cancers are aneuploid, with around ...
Polyploid giant cancer cells (PGCCs) contribute to solid tumor heterogeneity. This study investigated the relationships among PGCCs numbers, vasculogenic mimicry (VM) formation, and tumor grades in glioma.A total of 76 paraffin-embedded glioma tissue samples, including 28 cases of low grade and 48...
for 5 min. The supernatant was discarded, 500 μL of cell nucleus extract was added to prepare a cell nucleus suspension, 50 μL of DAPI (5 μg/mL) was added, and the cells were stained for 3–4 min in the dark and then tested on a CyFlow®Ploidy Analyzer (Sysmex-Partec GmbH)...
Considerable evidence suggests that breast cancer therapeutic resistance and relapse can be driven by polyploid giant cancer cells (PGCCs). The number of PGCCs increases with the stages of disease and therapeutic stress. Given the importance of PGCCs, it remains challenging to eradicate them. To ...
Accumulated evidence over the past decades indicates a very high prevalence of human cytomegalovirus (HCMV) in breast cancer. High-risk HCMV strains possess a direct oncogenic effect displayed by cellular stress, polyploid giant cancer cells (PGCCs) generation, stemness, and epithelial-to-...
Polyploid Giant Cancer Cells (PGCCs) have been recognized as tumor cells that are resistant to anticancer therapies. However, it remains unclear whether their presence in the bloodstream can be consistently detected and utilized as a clinical marker to guide therapeutic anticancer regimens. To address...
through the induction of dedifferentiation of mature human mammary epithelial cells (HMECs), generation of a polyploid giant cancer cell (PGCC) phenotype characterized by sustained growth of blastomere-like cells, in concordance with the acquisition of embryonic stem cells characteristics and epithelial...