Vascular endothelial growth factor (VEGF) is a potential therapeutic gene candidate for CNS disorders due to its specific roles in brain angiogenesis and neuroprotection. In this work, we elaborated three different non-viral vectors based on magnetic, cationic lipid and polymeric nanoparticles complexed...
Polymeric carriers for nucleic acid delivery: current designs and future directions Biomacromolecules (2019) P.R. Cullis et al. Lipid nanoparticle systems for enabling gene therapies Mol. Ther. (2017) P.P.G. Guimaraes et al. Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated...
Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy. Xie Y,Murray-Stewart T... Y Xie,T Murray-Stewart,Y Wang,... - 《Journal of Controlled Release》 被引量: 19发表: 2017年 Dual-Function Polymeric HPMA Prodrugs ...
Polyamine/DNA polyplexes with acid-degradable polymeric shell as structurally and functionally virus-mimicking nonviral vectorsGene deliveryVirus-mimicking synthetic vectorsPolyplex/shell nanoparticlesControlled intracellular deliveryBioavailable polyaminesAcid-degradable polymers...
Furthermore, they had remarkable antitumor efficacy in vivo with regard to the tumor growth retardation, gene knockdown, angiogenesis inhibition, and apoptosis induction in QGY-7703 tumor bearing mice. Therefore, tailoring of the binding strength between the polymeric vector and its siRNA cargo in ...
Keywords: polymeric nanoparticles; renewable polysaccharides; anionic starch; cationic anti-infectives; transfection 1. Introduction Nanoparticulate carrier systems represent a well established platform for vaccination and treatment of severe diseases, such as infection and cancer, by protecting active agents,...
Natural polymeric scaffolds in bone regeneration. Front. Bioeng. Biotechnol. 2020, 8, 474. [Google Scholar] [CrossRef] [PubMed] Stylios, G.; Wan, T.; Giannoudis, P. Present status and future potential of enhancing bone healing using nanotechnology. Injury 2007, 38, S63–S74. [Google ...
Non-viral gene delivery using exogenous microRNAs is a potential strategy for fighting cancers with poor prognosis and which lack specific therapies, such as triple-negative breast cancer (TNBC). Herein we report the synthesis of six nontoxic electrostatic polymeric nanocapsules (P1 to P6) for micro...
and Dmitry Vadimovich Goldshtein 1 , 1 Research Centre for Medical Genetics, 115478 Moscow, Russia 2 Central Research Institute of Dental and Maxillofacial Surgery, 119021 Moscow, Russia 3 Institute of Photon Technologies of Federal Scientific Research Centre "Crystallography and Photonics", Russian ...