Salviati, A novel mutation which represents the fifth non-pathogenic polymorphism in the coding sequence of the arylsulfatase A gene, Mol. Cell Probes. 11 (1997), 449-451.Perusi C, Gomez-Lira M, Mottes M, Pignatti PF, Rizzuto N, Salviati A. 1997. A novel mutation which represents the ...
由于SNP的发生频率非常之高,且每个人的DNA上所发生的SNP皆不同,故SNP常被当作一种基因标记(genetic marker),以用来进行研究。(1,4)SNP标记分布在基因组编码区或非编码区,存在在编码区的SNP约有20万个,称之为cSNP(coding SNP)。(15) SNP通常为双等位基因(Biallelic),所以SNP的变异不像STR那么大,但是因为SNP...
In this study, we demonstrate that a form of sensitivity analysis can be used to evaluate the effects of different methods of coding taxonomic polymorphisms on the outcome of phylogenetic analyses. Our earlier analysis of higher-level relationships of bats (Mammalia: Chiroptera) employed superspecific...
These SNPs all map to non-coding portions of the gene. As non-synonymous SNPs may be associated with functional changes of the protein, we have previously studied associations of rs8192678, the most frequent SNP in the coding region (minor allele frequency ~0.35) with HD AO, but found no...
in DNA, coding as well as noncoding. DNA sequencing has not only revealed more genetic variation than could be detected at the level of the protein, but the patterns of sequence variation between the coding and noncoding, and between the coding and control regions, are complex and rich and...
However, genetic association studies of the BDNF Val66Met polymorphism (single nucleotide polymorphism rs6265) in major depressive disorder (MDD) have produced inconsistent results. We conducted a meta-analysis of studies comparing the frequency of the BDNF Val66Met-coding variant in depressed cases ...
As most loci analysed in this paper originated as random fragments isolated from mating-type-specific chromosomes, no information with regard to coding regions is available; thus, we do not distinguish between silent and non-silent sites, and report DNA polymorphism and divergence for all sites ...
1 reagents referenced in A polymorphism site in the pre‑miR‑34a coding region reduces miR‑34a expression and promotes osteosarcoma cell proliferation and migration.
分布在基因编码区(coding region), 称之为cSNP,属功能性突变 SNP 在单个碱基或基因组的分布是不均匀的 非转录序列多与转录序列 在转录区非同义突变的频率,比其他方式突变的频率低得多 SNP 的意义 现在普遍认为 SNP 的研究是人类基因组计划走向应用的重要步骤,这是因为 SNP 可以在一下方面提供强有力的工具 ...
C++ Polymorphism - Learn about polymorphism in C++, including its types, benefits, and examples for better understanding of object-oriented programming.