Monogenic Trait vs. Polygenic Trait As mentioned earlier, a monogenic trait is a trait that results when a single gene or a pair of alleles is expressed. In one of Mendel’s breeding experiments, this would be exemplified by the seed color of the garden pea. A cross between a true-...
Qualitative Trait: the clinical condition is either present or absent. Quantitative Trait: the clinical condition with a measurable quantity that differs among individuals (measurable). For example:blood pressure, cholesterol level, height etc. Variation among individuals is due to ...
数量性状(quantitative trait) 130 140 150 160 170 180 190 200身高(cm) 8070605040302010 变异数 苯丙氨酸羟化酶活性 遗传控制 群体中性状变异的分布 相对性状的差异 举例 质量性状 单基因(一对主基因) 不连续 显著 垂体性侏儒,苯硫脲尝味能力 数量性状 多基因(多对主基因) 连续、正态 不显著 正常人的身高...
Samples selected from the Brains for Dementia Research (BDR) were used to produce gene expression data to identify potential expression quantitative trait loci (eQTLs) relevant to AD. These SNPs were then incorporated into a PRS model to classify AD and controls in the full BDR cohort. Models ...
Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes Article Open access 20 May 2024 Data availability We release our data at https://figshare.com/projects/Single-cell_Disease_Relevance_Score_scDRS_/118902 (ref. 72) (instructions ...
AF, atrial fibrillation; eQTL, expression quantitative trait locus; GWAS, genome-wide association study; MAF, minor allele frequency; MAGMA, Multi-marker Analysis of GenoMic Annotation; PoPS, polygenic priority score; snRNA-seq, single-nuclei RNA-sequencing. Extended Data Fig. 6 Gene set enrichment...
Indeed, quantitative genetics does not imply any straightforward reduction of phenotypes to single genes and seem to prevent popular discourses about the ‘gene for x,’ where x is any complex trait (see Kendler, 2006; Rutter, 2006; Sarkar, 1998). 5 In this sense, GWAS differ from classical...
Univariable logistic regression models were created using the R functionglmto test the association between sex, primary kidney disease, and each polygenic risk score trait and the odds of developing kidney failure before the age of 60. The effect of each polygenic risk score was investigated as a...
A previously published SCAD PRS consisting of 7 single-nucleotide variants (SNVs)4 was calculated for all genotyped individuals using PLINK version 1.9,22 as was a PRS for adult standing height consisting of 33 938 SNVs (height PRS),23 a trait with no known relationship with SCAD, which ...
Genetically driven DNAm is associated with gene expression of co-localizing genes Each EstiMeth model corresponds to a CpG that is likely to be under strong genetic control. Given the role of DNAm in the regulation of gene expression8, we investigated the relationship between EstiMeth CpGs and...