Thekey difference between polycystic kidney disease and hydronephrosisis that polycystic kidney disease is agenetic disorderthat causes fluid-filledcyststo grow in the kidneys, while hydronephrosis is a condition that causes one or both kidneys to become stretched and swollen due to the build-up...
to develop autosomal dominant polycystic kidney disease, one needs to inherit one copy of the mutated gene that is responsible for the disease. But to develop autosomal recessive polycystic kidney disease, one needs to inherit both copies
Polycystic kidney disease (PKD) is a common genetic disease that leads to kidney failure. Currently, the only approved treatment for this condition has only modest effects. However, calorie restriction was previously shown to inhibit disease progression in mouse models of PKD, but the mechanism rema...
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 and PKD2. However, genetic analysis is complicated by six PKD1 pseudogenes, large gene sizes, and allelic heterogeneity. We developed a new clinical assay for PKD gene analysis using paired-end next-generation ...