Polycystic kidney disease is characterized by localized autonomous cellular proliferation, compartmentalized fluid accumulation within the cysts, and intraparenchymal fibrosis of the kidney. The clinical features include renal failure, liver cysts, and vascular and cardiac valve abnormalities. Recent developments...
and other organisms. PKD is characterized by the presence of multiple cysts (hence, "polycystic") in both kidneys. The disease can also damage the liver,pancreas, and rarely, the heart and brain. The two major forms of polycystic kidney disease are distinguished by their patterns of ...
Polycystic kidney disease, an inherited systemic disorder, is characterized by the development of multiple cysts in the kidneys and other organs. Patients can present at any age, but more often come to clinical attention (unless there is a family history) after age 30. Patients who are diagnosed...
Another disease, autosomal recessive polycystic kidney disease (ARPKD), occurs in approximately 1 in 20,000 live births. The majority of patients are identified in utero or as infants with enlarged and echogenic kidneys. The liver lesion in ARPKD is characterized by the ductal plate malformation. ...
kidney disease characterized by enlarged kidneys containing many cysts; often leads to kidney failure 相似短语 polycystic kidney disease phr. 多囊性肾病 polycystic kidney 多囊肾 polycystic disease 【医】 多囊肿病 congenital polycystic kidney 先天性多囊肾 kidney disease phr. 肾脏病 fibro polycyst...
Keywords: polycystic kidney disease; drug discovery; kidney; candidate drugs; animal model Acta Pharmacologica Sinica (2011) 32: 805–816; doi: 10.1038/aps.2011.29 Introduction Polycystic kidney disease (PKD), an inherited human renal disease, is characterized by massive enlargement of fluid- filled...
Adult polycystic kidney disease is characterized by autosomal dominant inheritance, diffuse bilateral cystic kidney disease and onset during the young adult years. Relatively few cases of adult-type polycystic kidney disease in children have been reported. We describe a 4-year-old girl who appeared to...
either of two hereditary diseases characterized by gradually enlarging bilateral cysts of the kidney which lead to reduced renal functioning: a disease that is inherited as an autosomal dominant trait, is usually asymptomatic until middle age, and is marked by side or back pain, hematuria, urinary...
Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and is characterized by progressive growth of fluid-filled cysts. Growth factors binding to receptor tyrosine kinases (RTKs) stimulate cell proliferation and cyst growth in PKD. Nintedanib, a triple RTK ...
polycystic kidney disease noun : either of two hereditary diseases characterized by gradually enlarging bilateral cysts of the kidney which lead to reduced renal functioning: a : a disease that is inherited as an autosomal dominant trait, is usually asymptomatic until middle age, and is marked...