It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. 仅用于科研。不用于诊断过程。未经明确授权不...
别名: CPP32;CPP32B;SCA-1;Caspase 3;SREBP cleavage activity 1;Cysteine protease CPP32 产品编号: K003262P 储存液: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. 纯化方法: Affinity purification 蛋白分子量: 32kDa 交叉反应: Human Mouse Rat 克隆类型: Polyclonal Antibody 免疫原: Rec...
中文名称:Caspase-3 Rabbit Polyclonal Antibody 英文名称:Caspase-3 Rabbit Polyclonal Antibody 有效期: 一年 产品类别: 凋亡与自噬 Regulation of Apoptosis 产品编号 产品名称 产品包装 产品价格 AF0081 Caspase-3 Rabbit Polyclonal Antibody 50μl 询价 来源 用途 交叉反应性 分子量 Rabbit WB, FC, IHC, ICC,...
Proteolysis of PARP to its stable 85kDa fragment is an early marker of programmed cell death (apoptosis) and is mediated by the caspase CPP32 protein. Cleavage occurs between Adp216 and Gly217, a site in PARP conserved across species. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane...
Activated Caspase-9 in turn cleaves and activates Caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Recently, Cho et al (4) have identified a new Apaf 1 Interactiong Protein (APIP) also known as CG129 and MMRP...
Subcellular Locations:CytoplasmSwiss Prot:P42574 保存:Store at -20°C. Avoid freeze / thaw cycles.别名:CPP32;CPP32B;SCA-1;Caspase 3;SREBP cleavage activity 1;Cysteine protease CPP32 产品编号:K002117P储存液:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. ...
Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV ...
ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ...