Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9 Consistent with this, we found that XIAP antagonists were only capable of promoting the activity of caspase 9 when it was cleaved at Asp315, suggesting ... JB Denault,BP Eckelman,H Shin,.....
caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).,function:Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.,online information:Caspase-9 entry,PTM:Cleavages at ...
2216 PU.1 (9G7) Rabbit mAb (Alexa Fluor(R) 488 Conjugate) Monoclonal Antibody 500 ul CNY 3,694 9496S Cleaved Caspase-8 (Asp391) (18C8) Rabbit mAb Monoclonal Antibody 100 ul CNY 3,487 9496L Cleaved Caspase-8 (Asp391) (18C8) Rabbit mAb Monoclonal Antibody 300 ul CNY 8,360 2233 ...
protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ...
PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
Background Descriptions: Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/caspase-9 pathway. Smac/DIABLO binds to IAPs (Inhibitor of Apoptosis Proteins) and neutralizes the inhibitory effect of IAPs. Analysis of the ...
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of cas... PB Catalog Number: 被引量: 0发表: 0年 Polyclonal Anti- WASP PicobandTM Antibody E3 SUMO-protein ligase PIAS4, also known as protein inhibitor of activated STAT protein 4 (...
In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase. 包装清单: 产品编号 产品名称 包装 AF5333 XIAP Rabbit Polyclonal Antibody (KO Validated) 50μl AZ050 Western一抗...
Inhibitor: RX-0201. Substrates include tuberin, Bad, Forkhead transcription factors, caspase-9, and glycogen synthase kinase-3. 用途范围: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 产品信息订购: 产品货号 产品名称 规格 价格 大包装及货期 abs...
(mTOR) in a rapamycin-insensitive complex with rictor and Sin1. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad, forkhead transcription factors, c-Raf, and caspase-9. PTEN phosphatase is a major negative regulator of the ...