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Theoretical energy calculations also suggest that the right- and left-handed B- and D-DNA models are almost equally stable. Hence, we conclude that the right- and left-handed double-helical models of poly[d(I-C)] in a given form (B or D) are equally likely and that the fiber ...
T Reimer,M Brcic,M Schweizer,TW Jungi 摘要: Macrophages play major roles in the onset of immune responses and inflammation by inducing a variety of cytokines such as TNF and IFN-beta. The pathogen-associated molecular pattern, polyinosinic-polycytidylic acid [poly(I:C)], and LPS were used ...
Poly(I. C), a potent inducer of interferons (IFNs) in vivo, enhanced the susceptibility of CB-17 SCID mice to acute systemic candidiasis and to systemic candidiasis of endogenous origin, as demonstrated by increased numbers of viable Candida albicans in internal organs after poly(I. C) ...
ObjectivesPoly (ADP-ribose) polymerase (PARP) has been proposed to play an important role in the pathogenesis of heart ischaemia/reperfusion (I/R) injury. 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone (DPQ), a novel, poten... ZF Song,DY Chen,D Bo,... - 《Heart》...
The expression of pSTAT3/STAT3 and Runx2 was analyzed by western blot (c), and the calcium deposition was quantified by the calcium assay (d). (n = 5 per group). e The phosphorylation of JAK2 and SRC, and their total proteins in calcified VSMCs infected with Scr shRNA or PARP...
We show that uptake of poly(I:C)-induced apoptotic tumour cells leads to DC maturation and activation with a Th1 cell polarising capacity. In contrast, these effects are not seen by DCs loaded with γ-irradiated apoptotic tumour cells. We propose that the manner in which tumour cells are ...
c Top: PARG-1::GFP localization in a wild-type gonad. Scale bar 30 μm. Bottom: enlarged insets showing dynamic localization of PARG-1::GFP in different stages of meiotic prophase I. Scale bar 5 μm. Analysis was performed in biological triplicates. d Mid- and late-pachytene ...
M Carafa,C Marianecci,F Rinaldi,... - 《International Journal of Nanomedicine》 被引量: 16发表: 2014年 Skin repair properties of d-Limonene and perillyl alcohol in murine models. The orange-peel derived terpene d-Limonene, probably through its metabolite, perillyl alcohol (POH), has been re...