Poly-4-hydroxybutyrateComponents separationPoly-4-hydroxybutyric acid (P4HB, Phasix) is a biosynthetic polymer that degrades by hydrolysis that can be woven into a mesh for use in soft tissue reinforcement. Herein, we describe our initial experience performing complex abdominal wall repair (CAWR) ...
Poly(4-hydroxybutyrate) (P4HB), belonging to the family of bacterial polyhydroxyalkanoates (PHAs), is a strong, flexible and absorbable material which has a large variety of medical applications like tissue engineering and drug delivery. For efficient production of P4HB recombinantEscherichia coliha...
poly-4-hydroxybutyratepolyhydroxyalkanoatewet spinningPolyhydroxyalkanoates (PHAs), also known as bacterial polyesters, are considered novel polymers for fabricating biomedical products, such as sutures and hernia meshes, because of their biocompatibility and slow biodegradability. Poly-4-hydroxybutyrate (...
We aim to evaluate the efficacy, safety, and patient reported outcomes (PROs) of patients undergoing CVHR with onlay Poly-4-hydroxybutyrate (P4HB). Methods Adult (>18 y old) patients undergoing VHR with P4HB (Phasix) in the onlay plane by a single surgeon from 01/2015 to 05/2020 were...
Compositions of P4HB (poly-4-hydroxybutyrate) and copolymers thereof, have been developed for pultrusion, as well as processes to produce profiles from these compositions by pultrusion. These pultrusion processes provide profiles without causing structural damage to the surface of the profile. The ...
In contaminated wounds, poly-4-hydroxybutyrate meshes seem superior to conventional synthetic meshes. Abstract Introduction and importance An infection of anabdominal wallprosthesis can be a real disaster for the patient. A conservative treatment might be an option if biological or slowly resorbable synth...
THERMOFORMED POLY-4-HYDROXYBUTYRATE MEDICAL IMPLAN 专利名称：THERMOFORMED POLY-4- HYDROXYBUTYRATE MEDICAL IMPLANTS 发明人：BERNASCONI, Matthew,CONNELLY, Dennis W.,RIZK, Said,MARTIN, David P.,WILLIAMS,Simon F.申请号：EP17189272.2 申请日：20140820 公开号：EP3305338A1 公开日：20180411 专利内容由知识...
1. A foam composition comprising poly-4-hydroxybutyrate and copolymers thereof, wherein the foam contains closed cells. 2. The structure of claim 1 wherein the foam has an open cell content of less than 50%. 3. The structure of claim 1 wherein the foam has a density of less than ...
Methods to produce thermoformed implants comprising poly-4-hydroxybutyrate homopolymer, copolymer, or blend thereof, including surgical meshes, have been developed. These thermoforms are preferably produced from porous substrates of poly-4-hydroxybutyrate homopolymer or copolymer thereof, such as surgical mes...
In this work, a Bacillus megaterium strain was engineered to generate poly(3-hydroxybutyrate-co-4-hydroxybutryate) (P[3HB-co-4HB]) copolymers, which are among the most useful and industrially-relevant copolymers. These copolymers had lower modulus and increased toughness, thus making the ...