Nontoxic, targeted poly beta- amino esters (PBAEs) are synthesized by using click chemistry to attach a targeting moiety. The click chemistry uses a dienophile, such as a strained alkene ring, and a diene, such as tetrazine, to provide rapid attachment of targeting moieties to PBAE polymers ...
polymers which are poly (beta-amino esters) (pbaes) modified with at least one oligopeptide are described. The polymers may be used in any field where the polymers have been found to be useful, including in the fields of medicine, particularly in drug administration. The polymers are ...
In this work, we present the development and assessment of a library of mannosylated poly(beta-amino esters) (PBAEs) that represent a new class of easily synthesized APC-targeting cationic polymers. Polymeric characterization and assessment methodologies were designed to provide a more realistic ...
We have overcome the challenge by developing a system that employs electrostatic attraction between the negatively charged constituents of cartilage and a positively charged polymer, poly-beta amino esters (PBAEs). We have demonstrated cartilage uptake of dexamethasone (DEX) covalently bound to the ...
COMPLEXES OF VIRAL-BASED THERAPEUTIC AGENTS AND MODIFIED POLY(BETA-AMINO ESTERS)Disclosed are complexes of virus-based therapeutic agents with polymers that are poly(beta-amino ester)s (PBAEs) modified with at least one oligopeptide. Also disclosed are methods of treatment using these complexes and...
PhosphonateMechanical propertiespH sensitivity, biodegradability and high biocompatibility make poly(beta-amino esters) (PBAEs) important biomaterials with many potential applications including drug and gene delivery and tissue engineering, where their degradation should be tuned to match tissue regeneration ...
COMPLEXES OF VIRAL-BASED THERAPEUTIC AGENTS AND MODIFIED POLY(BETA-AMINO ESTERS)Disclosed are complexes of virus-based therapeutic agents with polymers that are poly(beta-amino ester)s (PBAEs) modified with at least one oligopeptide. Also disclosed are methods of treatment using these complexes and...
complexes of virus-based therapeutic agents with polymers that are poly (beta-amino esters) (pbaes) modified with at least one oligopeptide are described. treatment methods using these complexes and methods of encapsulating said complexes to form nanoparticles are also described.ANNA ASCANTE CIRERA...