Mela- tonin, the main indolamine secreted by the pineal gland has two important properties which play a key role in the main- taining of neuron polarization: it is a potent free radical scavenger, and it is a cytoskeletal modulator. Melatonin stimulates cytoskeletal polarization through PKC and...
polarization pertains to the act or process of producing a positive electrical charge and a negative electrical charge such that between a nerve cell internal electrical charge, which is negative, and the surrounding environment of a nerve cell, which is positive. The cell is able to regulate ...
Cell viability and apoptosis of neuron-like PC12 cell line co-cultured with BV2 were detected. TLR4 RNA transcript and protein abundance in mesencephalic tissue and BV2 cells were detected. Nuclear factor kappa-gene binding (NF-魏B) p65 subunit phosphorylation both in vitro and ...
Implementation of Neuron-level Structured Pruning using Polarization Regularizer - bochen-sysnet/PolarizationPruning
Implementation of Neuron-level Structured Pruning using Polarization Regularizer - polarizationpruning/PolarizationPruning
Therefore, we speculated that NP may promote the death of enteric neurons by inducing polarization of macrophages towards the M1 phenotype. In NP-treated mice model, TuJ1 (a neuron marker) (Song et al., 2024) and p75 (a neural crest marker) (Wislet et al., 2018) positive cells were ...
On the contrary, M2 is an anti-inflammatory type, which can produce anti-inflammatory factors to inhibit the inflammatory response and promote neuron regeneration and repair [13]. When MG are in a resting state, the cytoplasmic NF-κB binds to the Inhibitor of NF-κB (IκB) protein. When ...
Paolicelli RC et al (2022) Microglia states and nomenclature: A field at its crossroads. Neuron 110:3458–3483 PubMed PubMed Central CAS Google Scholar Pelucchi S, Stringhi R, Marcello E (2020) Dendritic Spines in alzheimer’s disease: how the actin cytoskeleton contributes to synaptic failu...
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis and attenuate OA progression have been scarce
The in vivo status of activated microglia is probably on a continuum between these two extreme states. However, the mechanisms regulating microglial polarity remain elusive. Here, we addressed this question focusing on minocycline. We used SOD1G93A mice as a model, which exhibit the motor neuron...