A method for library design that incorporates both rational design and combinatorial diversity relies on the "binary patterning" of polar and nonpolar amino acids. Binary patterning is based on the premise that the appropriate arrangement of polar and nonpolar residues can direct a polypeptide chain ...
One kind of nonpolar covalent bond that is very important in biology is called a peptide bond. A peptide bond joins together chains of amino acids, which are involved in the construction of proteins. Amino acids are comprised of several atoms like carbon, oxygen, nitrogen and hydrogen....
Thephospholipid bilayerforms the basic structure of the membrane. Each phospholipid molecule has a polar head that is charged and two nonpolar hydrocarbon tails from fatty acids. A polar head is hydrophilic. It is so-called since it attracts polar water molecules. Nonpolar tails are hydrophobic, ...
我们发现,O4最强烈方式与短期aβ42多肽,包含nonpolar、疏水氨基酸(例如,多肽12、12 vhhqklvffa21、或多肽24,24vgsnkgaiig.33),而与极地氨基酸肽(例如,多肽1、1daefrhdsgy.10)是很软弱无力或不承认在所有 翻译结果5复制译文编辑译文朗读译文返回顶部 我们发现O4与包含无极,疏水氨基酸的短的Aβ42肽强烈互动(例如...
Kamtekar S, Schiffer JM, Xiong H, Babik JM, Hecht MH (1993) Protein design by binary patterning of polar and nonpolar amino acids. Science 262:1680-5Kamtekar, S., Schiffer, J. M., Xiong, H., Babik, J. M. and Hecht, M. H.: 1993, Protein Design by Binary Patterning of Polar ...
Protein design by binary patterning of polar and nonpolar amino acids. Science 262:1680-1685, 1993.Kamtekar S, Schiffer JM, Xiong H, Babik JM, Hecht MH (1994) Protein design by binary patterning of polar and non polar aminoacids. Science 262:1680–1685...
1997b . A protein designed by binary patterning of polar and nonpolar amino acids displays native-like properties . J. Am. Chem. Soc. 119 : 5302 – 5306 .Roy S, Ratnaswamy G, Boice JA, Fairman R, McLendon G, Hecht MH. 1997. A protein designed by binary patterning of polar and ...
These 100 proteins were further probed to generate Ramachandran plot/data for the gross secondary structure prediction in and comparison between the thermophilic and mesophilic proteins.Present results strongly suggest that nonpolar smaller volume amino acids Ala (蠂2 = 238.54, p<0.001) and Gly (蠂2...
Kamtekar S, Schiffer JM, Xiong H, Babik JM, Hecht MH (1993) Protein design by binary patterning of polar and nonpolar amino acids. Science 262:1680–1685S. Kamtekar, J. M. Schiffer, H. Xiong, J. M. Babik, and M. H. Hecht. Protein design by binary patterning of polar and ...
Preparing hot saturated aqueous solutions of at least two different amino acids, one polar hydrophilic and another nonpolar hydrophobic, mixing, dryingdoi:US5756761 AA process for improving the solubility of hydrophobic amino acids in which hot saturated aqueous solutions of at least two different ...