In case of aberrant caloric load, TAGs are deposited into non-adipocyte tissues, primarily liver cells. For instance, non-alcoholic fatty liver disease (NAFLD) is a common chronic disorder characterised by an excess of TAG in the liver of patients regardless of their susceptibility to obesity, ...
Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense ... S He,C Mcphaul,JZ Li,... - 《Journal of Biological Chemistry》 被引量: 1242发表: 2010年 Pnpla3/Adiponutrin deficiency in mice does...
Its mRNA is distributed in a variety of human tissues, but is absent in the mouse genome [6,89]. Human PNPLA4 possesses a potent retinol ester hydrolase activity, which regulates the cellular levels of all-trans-retinoic acid [530,531]. This reaction may contribute to epidermal morphogenesis...
PNP Therapeutics has demonstrated that combining fludarabine phosphate (F-araAMP) andE. coliPNP results in exceptional anti-tumor activity in preclinical models. These results have been confirmed by many other research groups from around the world. Based upon these preclinical results, we have initiate...
2A, B). As expected, Pnpla3 mRNA expression was decreased in a gene-dose-dependent manner in mice carrying the targeted allele and was completely absent in Pnpla3-KO mice in metabolically-relevant tissues where the Pnpla3 gene is normally expressed (i.e., in adipose tissue, adrenal ...
(1998) Distribution of PNP 14 ((3-synuclein) in neuroendocrine tissues: localization in Sertoli cells. Mol. Reprod. Dev. 50 , 163–169.Shibayama-Imazu, T., Ogane, K., Hasegawa, Y., Nakajo, S., Shioda, S., Ochiai, H., Nakai, Y., and Nakaya, K. (1998). Distribution of PNP ...
Cardiovascular Diabetology (2023) 22:64 Page 2 of 8 Introduction Insulin resistance (IR) refers to a decreased sensitivity of peripheral tissues to insulin and is a hallmark pathophys- iologic feature of type 2 diabetes mellitus (T2DM) that clinically develops when the β-cell compensatory mech-...
(PNP) catalyzes the phophorolysis of N-ribosidic bonds of purine nucleosides and deoxynucleosides. Physiological substrates of PNP include inosine, guanosine, and 2'-deoxyguanosine, but not adenosine (1). PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. ...
Liver biopsy tissues were stained with hematoxylin and eosin, reticulin and Masson's trichrome stain. The histological criterion for NAFLD diagnosis is macrovesicular fatty change in hepatocytes with displacement of the nucleus toward the cell edge.15 Patients who had more than 5% of hepatocytes ...
It must be noted that the amino acid sequence of the mouse PEDF-R is identical to the mouse adipose triglyceride lipase (ATGL) and desnutrin, which have been reported extensively in tissues outside of the eye (11). Here, we refer to the gene and its protein as Pnpla2 and PEDF-R, ...