Lastly, I148M overexpressing cells exhibit a higher LPAAT activity compared to PNPLA3 wild-type overexpressing cells, arguing in favor of a gain-of-function [53]. Sign in to download full-size image Figure 1. A simplified model showing the regulation of PNPLA3 gene expression in liver and...
Full size image Inactivation of PNPase leads to mutant phenotypes of Listeria monocytogenes Changes in cell size, shape, and motility have been associated with virulence defects of bacterial pathogens as these traits may affect host invasion41,42. To determine if the difference in the colonization...
Download: Download full-size image Fig. 2. Box-and-whisker plots illustrating liver function tests in carriers of distinct PNPLA3, TM6SF2, and MBOAT7 variants. Carriers of either PNPLA3 or TM6SF2 risk alleles present with increased AST and ALT activities (A and B for PNPLA3; D and ...
Full-length 30UTR sequences of PNP mRNA and specific miRNA target sequences (Supplementary Table 1) for miR-1 and miR-133a were artificially synthesised and inserted into the vector. In addition, we constructed three mutant vectors in which the specific miR-1 and miR-133a as tumour ...
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National Instruments products are NOT intended to be a substitute for any form of established process, procedure, or equipment used to monitor or safeguard human health and safety in medical or clinical treatment. Table of Contents About This Manual Organization of This Manual ... ix Conventions U...
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Like its full-sized counterpart, the all-new FMS 1400mm J-3 V4 has excellent short takeoff and landing (STOL) and slow speed handling characteristics. FMS has dedicated significant amount of resources in making this aircraft as detailed as possible- components such as the engine and landing gea...
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Full size image Conformational plasticity of the C-terminal kinase extension An unexpected feature of the CDK12715–1052/CycK11–267 complex structure is the conformational plasticity of the C-terminal kinase extension. The conformation of the two CDK12 molecules in the asymmetric unit diverges followi...