Serotype distribution of invasive pneumococcal dis- ease during the first 60 days of life. Vaccine. 2010;28: 4758-4762.Imohl M, van der Linden M, Mutscher C, Reinert RR (2010) Serotype distribution of invasive pneumococcal disease during the first 60 days of life. Vaccine 28(30): 4758-...
Unlike PCV7, PCV13 includes serotype 19A, which is the most common serotype causing invasive pneumococcal infections in children. In addition to serotype 19A, PCV13 also contains conjugated antigens representing serotypes 1, 3, 4, 5, 6A and B, 7F, 9V, 14, 18C, 19F, and 23F. The FDA ...
pneumoniae serotype was not identified (group C). The sensitivity was 62% (group A). A heterotypic antibody rise was observed in one patient (group B). There was no difference in antibody rises between groups A and C. In 13 patients the pulmonary infiltrates were associated with different ...
PCVs were generally assumed to have serotype-specific effectiveness equal to PCV13 efficacy in the pivotal trial, though four studies used estimates from a Delphi panel; protection was assumed to last between 10 and 20 years. PPSV23 was assumed to have lower effectiveness against non-bacteremic...
CcrZ is a conserved bacterial cell cycle protein We previously generated a knockdown library using CRISPRi targeting 348 conditionally essential genes of the serotype 2 strainS. pneumoniaeD39V that were identified by transposon-insertion sequencing26. Here, we investigated the function ofspv_0476, enc...
Serotype-specific functional antibodies were assessed using a validated OPA as previously described [15,16]. Titres below LLOQ were set to half of LLOQ (Supplement 3). All pneumococcal antibody analyses were undertaken with blinded samples at the Pfizer Pearl River Laboratory, USA. Definition of se...
Miyaji EN, Oliveira MLS, Carvalho E, Ho PL (2012) Serotype-independent pneumococcal vaccines. Cell Mol Life Sci. doi:10.1007/s00018-012-1234-8 About this Article Title Fred Neufeld and pneumococcal serotypes: foundations for the discovery of the transforming principle Journal Cellular and Molec...
Responses were found to vary markedly with the age at the time of immu- nization and with the pneumococcal serotype tested. Three general patterns of isotype-specific antibody response were observed in the infants: a high response in IgG antibody occurred as early as 2 months of age following...
Methods: Eleven-day old rats were intracysternally infected with Streptococcus pneumoniae serotype 3, or saline, treated with B12 or placebo, and, 24 h after infection, their hippocampi were analyzed for apoptosis in the dentate gyrus, sulfur amino acids content, global DNA methylation, ...
Finally, we discuss serotype-specific virulence determinants of pneumococcus that may contribute to the patterns of colonisation and invasive pneumococcal disease in the young and the elderly as well as current and future approaches to immunisation for protection against pneumococcal disease....