The fusion proteins contained variable portions of the PML N terminus joined to the B-F RAR alpha domains; the only PML region retained was the putative DNA binding domain. The aberrant PML proteins lacked the C terminus, which had been replaced by from two to ten amino acid residues from ...
PML-RARalpha protein PML-RARalpha protein(PML-RARalpha protein) CAS: 化学式: 主页 产品 PML-RARalpha protein 中文名PML-RARalpha protein 英文名PML-RARalpha protein 英文别名PML-RARalpha protein
The PML-RAR alpha hybrid protein generated by the t(15;17) translocation in acute promyelocytic leukemia (APL) is thought to play a central role in the oncogenic process. However, analysis of the oncogenic activity of the fusion protein in tissue culture assays or in mice has been hampered ...
Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute pro- myelocytic leukemia. Leukemia. 1997;11:1950-6.Kitamura, K., Kiyoi, H., Yoshida, H., Saito, H., Ohno,...
A RESEARCH FLOW CYTOMETRIC BEAD ASSAY FOR THE DETECTION OF PML-RAR alpha FUSION PROTEIN IN ACUTE MYELOID LEUKEMIA 来自 ResearchGate 喜欢 0 阅读量: 13 作者:D Greenberg,E Hsi,E Dixon,YP Liu,C Bush-Donovan 会议名称: 24th Annual Meeting of the Clinical-Cytometry-Society ...
Five acute promyelocytic leukemia (APL) patients who achieved a complete remission (CR) with all-trans retinoic acid (ATRA) underwent residual disease monitoring through reverse transcription polymerase chain reaction (PCR) for PML/retinoic acid receptor-alpha (PML/RAR alpha) fusion transcript. All re...
PML/RAR alpha APL with undifferentiated morphology and stem cell immunophenotype (letter). Leukemia 1998; 12: 1492-1493.Foley R; Soamboortsrup P; Kouroukis T;.PML/RAR alpha APL with undifferentiated morphology and stem cell immunophenotype.Leukemia.1998.1492-1493...
Mechanism for ubiquity- lation of the leukemia fusion proteins AML1-ETO and PML-RAR{alpha}. FASEB J 2008b;22(5):1369-79.Kramer OH,Miiller S,Buchwald M,et al.Mechanism for ubiquitylation of the leukemia fusion proteins AML 1-ETO and PML-RARalpha.The FASEB Journal. 2008...
ALPHA(1)-ADRENOCEPTORCA2+ CHANNEL CURRENTNEONATAL RAT VENTRICULAR CELLYOUNG RAT VENTRICULAR CELLAcute promyelocytic leukemia (APL) is characterized by a specific t(15;17) translocation that fuses the retinoic acid receptor alpha (RAR alpha) to a novel gene product, PML. The involvement of RAR ...
Bolufer P, Barragan E, Sanz MA, Martin G, Bornstein R, Colomer D, et al: Preliminary experience in external quality control of RT-PCR PML-RAR alpha detection in promyelocytic leukemia. Leukemia 1998.12(12):2024-28.Bolufer, P., BarragaAn, E., Sanz, M.A., MartAon, G., Bornstein, R...