pml-nbs网络核体 网络释义 1. 核体 关键词: 早幼粒白血病蛋白核体(PML-NBs); SUMO化修饰; 病毒感染; 摘要: 早幼粒白血病蛋白核体(promyelocytic leukaemia nucle…med.wanfangdata.com.cn|基于4个网页 隐私声明 法律声明 广告 反馈 © 2025 Microsoft...
PML降解应激凋亡PML核体(PML-NBs) 是一种相对稳定的结构,但其数目,大小和位置在细胞压力下可发生显著改变.如热休克及重金属会导致PML-NBs裂解成数目众多的小点.DNA损伤试剂, 如Cisplatin和Alkylating试剂也可导致PML-NBs分散成更小的小体,甚至呈现一种弥散的状态.虽然先前的研究试图解释这些压力状态 下PML-NBs的...
Lindsay CR,Morozov VM,Ishov AM.PML NBs (ND10)and Daxx:from nuclear structure to protein function.Frontiers in Bioscience. 2008Lindsay CR, Morozov VM, Ishov AM: PML NBs (ND10) and Daxx: from nuclear structure to protein function. Front Biosci 2008, 13:7132-7142....
SUMO-1可共价修饰PML蛋白,是后者定位到NB的前提。SUMO-1修饰的PML-NBs能够进一步招募其他蛋白质,从而调节其功能,其中SUMO可以作为PML/p53通路中的一种调节蛋白。当PML作为转录催化因子与p53结合时,会抑制肿瘤细胞生长,并激活p53的促凋亡活性。另外,GFP-SUMO-1的过表达能阻止PML-NB的微结构形成,其原因是从PML修饰...
PML nuclear bodies (PML NBs) respond to many cellular stresses including viral infection, heat shock, arsenic and oncogenes and have been implicated in the regulation of p53-dependent replicative senescence and apoptosis. Recently, the hMre11/Rad50/NBS1 repair complex, involved in Double Strand ...
研究表明,PML-NBs也是多种病毒入侵细胞的作用靶点。PML-NBs通过介导细胞固有免疫反应或者作为细胞干扰素信号通路元件参与宿主细胞的抗病毒防御活动。该文以几种DNA和... 王涤,郑雅宏,雷鸣 - 《中国细胞生物学学报》 被引量: 2发表: 2012年 喉癌中SP100表达及生物学功能研究 SP100蛋白,全名为SP100核抗原(SP100 ...
(PML) nuclear bodies (NBs),small nuclear sub-structures,contribute to the repression of HSV-1 infection in the absence of functional ICP0.In this review,we discuss the fundamentals of the interaction between ICP0 and PML NBs,suggesting a potential link between PML NBs and ICP0 in regulating ...
(PML-NBs).19,20 p53 tumor suppressor is recruited to PML-NBs where it became acetylated and activated, and participate in the triggering of cellular senescence.17,18,21,22 In addition, PML itself is regulated by acetylation and subse- quent sumoylation,23 and PMLIV sumoylation has been ...
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