We pool all drugs together because they have similar targets inspired by the notion of “umbrella” trials to identify the efficacy of different drugs, based on different mutations in one cancer.39 This design can validate a treatment strategy involving a mixture of agents and has been ...
Shinya Tsukamoto is one weird dude, and both of these films are intensely over-the-top in a characteristically Japanese way. I expectedBullet Balletto be a John Woo-style shoot-em-up, but it's not that at all. As I understand it, handguns are very hard to come by in Japan – unless...
However, exceptions are made when one year has elapsed since the loss of qualification and the consent to use the service has been obtained from the "company". 2. When the user's name is not a real name or someone else's name is used 3. When the user provides false information or ...
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Toxicity Patients receiving fluorouracil plus folinic acid had significantly increased grade 3/4 stomatitis (P < .001) and diarrhea (P < .001), whereas patients receiving gemcitabine reported significantly increased grade 3/4 hematologic toxicity (P = .003) (Table 2). One hundred seventeen patient...
One of the factors in the observed lack of superiority of stenting over medical therapy may be related to the nonnegligible periprocedural complications. The rate of 30-day symptomatic intracranial hemorrhage was numerically higher in the stenting than the medical therapy alone group (2.3% [4/176]...
Overall, grade 4 AEs were reported in nine patients (20.0%): four patients (8.9%) experienced neutropaenia, two patients (4.4%) presented with a decreased neutrophil count, and one case (2.2%) each of febrile neutropaenia, thrombocytopaenia and peripheral sensory neuropathy was reported. A ...
Two out of seven quantitative studies examining impacts on HIV incidence/prevalence found a protective association. (Protective effects were found in one of the three interventions that included HIV testing/prevalence). Two of these studies found a protection association with the time trend over the ...
The results demonstrated that all patients had at least one enlarged OV (≥6 mm) with reflux (Hiromura grade II-III), retaining the contrast agent for ≥20 seconds, pelvic venous plexus congestion, ipsilateral (or contralateral) IIV filling, and/or vulvar and thigh varicose vein filling.9,13...
Six or seven standard I/O pads are grouped with a GND pad and either a VDD (core power) or VDDP (I/O power) pad. Two reference bias signals circle the chip. One protects the cascaded output drivers, while the other creates a virtual VDD supply for the I/O ring. I/O pads are...