5/聚乳酸(PLA-P85-PLA)纳米粒子并考察其形态及体外释放行为。方法:采用本体聚合法合成PLA-P85-PLA嵌段共聚物,透析法制备PLA-P85-PLA纳米粒子,UV测定包封率,HPLC测定紫杉醇的体外释放行为,MTT测定纳米粒子的生物相容性。HPLC条件为流动相乙腈-PBS(50∶50),检测波长227 nm。结果:包埋紫杉醇的PLA-P85-PLA纳米粒子粒...
Small-angle neutron scattering (SANS) has been used to investigate Pluronic P85 (EO 26PO 40EO 26) copolymer in deuterated water. A range of P85 fractions were measured for a wide sample temperature window. A rich phase behavior is reported. Unimers were observed below the critical micelle ...
目的:制备包埋紫杉醇的Pluronic P85/聚乳酸(PLA-P85-PLA)纳米粒子并考察其形态及体外释放行为.方法:采用本体聚合法合成PLA-P85-PLA嵌段共聚物,透析法制备PLA-P85-PLA纳米粒子,UV测定包封率及载药量,HPLC测定紫杉醇的体外释放行为,MTT测定纳米粒子的生物相容性.HPLC条件为流动相乙腈-PBS(50:50),检测波长227 nm.结...
摘要 本发明一种含PluronicP85聚合物及其制备方法与应用,属于生物医药领域,公开了一种含有叶酸靶向基团的、由聚氧乙烯‑氧丙烯‑氧乙烯作为亲水链段、聚丙交酯作为疏水链段的两亲性嵌段具有新型化学结构的聚合物叶酸‑聚氧乙烯‑聚氧丙烯‑聚氧乙烯‑聚乳酸(FA‑P85‑PLA),以及该化合物的制备方法。本发明具有...
The HepG2 cells treated with MB/P85 or without treatment were exposed to ultrasound (US parameters: 1 MHz, 0 W/cm2, 20 s, 20% duty cycle). Twenty-four hours later, the transfection efficiency was assessed by fluorescence microscopy and fluorescence activated cell sorting (FACS) analysis. ...
实验结果如下:1.以三种不同嵌段组成的Pluronic(F127,F87及P85)为修饰剂,采用传统的薄膜分散法结合DHPM技术,制备Pluronic修饰的脂质体,以未修饰的脂质体为对照。结果表明,Pluronic F127、F87和P85修饰使得脂质体粒径变小,修饰后的脂质体均呈单层球形结构,修饰脂质体的膜稳定性按以下顺序排列:Lps<F87-Lps<F127-...
Purpose . The amphiphilic block copolymer Pluronic P85 (P85) increases the permeability of the blood-brain barrier (BBB) with respect to a broad spectrum of drugs by inhibiting the drug efflux transporter, P-glycoprotein (Pgp). In this regard, P85 serves as a promising component for CNS drug...
842 JHuazhongUnivSciTechnol[MedSci] DOI10.1007/s11596—011-0688—5 31(6):842·845,2011 CombinedPluronicP85..and GeneTransfectiontoHepG2 Ultra .soundContrastAgents—mediated Cells。 XijunZHANG(张喜君)一,KaiyanLI(李开艳),XianCUI(崔贤),LiangjunHU(胡良军),YunchaoCHEN(陈云超) DepartmentofUltrasound,...
求翻译:pluronic p85是什么意思?待解决 悬赏分:1 - 离问题结束还有 pluronic p85问题补充:匿名 2013-05-23 12:21:38 普朗尼克P85 匿名 2013-05-23 12:23:18 pluronicp85 匿名 2013-05-23 12:24:58 pluronic p85 匿名 2013-05-23 12:26:38 pluronic p85 匿名 2013-05-23 12:28:18 ...
求助pluronic P85 在国内哪里能买到？ BASF好像有 但一直联系不到 问过的代理商查不到该辅料 说...