As such, the inhibition of tryptophan synthase along with other PLP-enzymes in amino acid metabolism has the potential to help solve medical problems. WikiMatrix In that regard, the applicants submit that the Commission erroneously assessed the evidence adduced in support of the allegation of infri...
The principal existence of natural catalytic antibodies in the autoimmune sera is discussed. In the course of the autoimmune process, the induction of antiidiotypic antibodies against topoisomerase I has been shown in the sera of patients with scleroderma, systemic lupus erythematosus, and rheumatoid ...
Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation Pyridoxal 5'-phosphate (PLP), the biologically active form of vitamin B6, is an important cofactor in amino acid metabolism, and supplementary vitamin B6 h... MDM Huq,NP Tsai,YP Lin,... - 《Nature ...
Dopa decarboxylase (DDC), a pyridoxal 5'-phosphate (PLP) enzyme responsible for the biosynthesis of dopamine and serotonin, is involved in Parkinson's dise... F Daidone 被引量: 0发表: 2012年 Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. The first step in the biosynthesis...
Among PLP-dependent metabolism, supersulfide synthesis was suppressed in prolonged hypoxia, resulting in the lysosomal inhibition and consequent proinflammatory phenotypes of macrophages. The PNPO–PLP axis creates a distinct layer of oxygen sensing that gradually shuts down PLP-dependent metabolism in ...
Vascular repair is considered a key restorative measure to improve long-term outcomes after ischemic stroke. N6-methyladenosine (m6A), the most prevalent internal modification in eukaryotic mRNAs, functionally mediates vascular repair. However, whether c
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Pyridoxal phosphate-dependent enzymes catalyze a wide variety of reaction types on amines and amino acids, generally by stabilizing carbanionic intermediates, which makes them very common in both primary and secondary metabolism. A fundamental mechanism by which reaction specificity is enforced is ...
Cysteine methionine metabolismPyridoxal-5'-phosphateSubstrate specificityThe crystal structure of cystathionine γ-lyase (CGL) from yeast has been solved by molecular replacement at a resolution of 2.6 Å. The molecule consists of 393 amino acid residues and one PLP moiety and is arranged in the ...
Bacillus subtilis GabR is a transcription factor that regulates gamma-aminobutyric acid (GABA) metabolism. GabR is a member of the understudied MocR/GabR s... R Edayathumangalam,R Wu,R Garcia,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量:...