To reveal further pleiotropic, beneficial effects of aspirin on a number of pro- and anti-inflammatory microglial mechanisms, we performed morphometric and functional studies relating to phagocytosis, pro- and anti-inflammatory cytokine production (IL-1, tumor necrosis factor-卤 (TNF-卤) and IL-10...
In response to microbial molecules of Ausome, immune cells produce pro-inflammatory cytokines, including IFN-γ, TNF-α and IL-6. Although these cytokines are to be protective, the excessive inflammatory response may cause tissue injury and even life-threatening cytokine storm34,35. To this end,...
The activation ultimately results in the recruitment and activation of cytotoxic immune cells and the amplification of inflammatory immune responses. Notable cytokine interactions include IL-23 promotion and IL-33 restriction of IL-17 production, which in turn amplifies and inhibits inflammation through ...
comparison with a non-cleavable MDA5 mutant protein with preserved antiviral activity. The Lpro cleavage site in MDA5 was identified as the RGRAR sequence in the conserved helicase motif VI, coinciding with that recently reported for Lpro in LGP2, another member of the RLRs family involved in...
(NVU). Ischemic stroke triggers endothelial cell dysfunction, resulting in the breakdown of the BBB, which allows inflammatory cells to infiltrate the vasculature and enter the central nervous system. Additionally, this condition activates microglia, driving their transformation into a pro-inflammatory ...
Finally, studies in humans showed that GOS significantly increased the numbers of bifidobacteria, phagocytosis, NK cell activity, and anti-inflammatory IL-10 in healthy elderly individuals, with a significant reduction in the production of pro-inflammatory cytokines (IL-6, IL-1β, and tumor ...
IL-1β is a pro-inflammatory cytokine, and its abnormally high expression is a predictive biomarker of tumor malignancy and increased risk of bone metas- tasis from breast cancer [37]. IL-1β can be triggered by inflammatory signaling in multiple immune types and is an important factor and ...
Then, activation of IRF3 and NF-κB leads to the pro- duction of type-I interferon (IFN), pro-inflammatory cytokines and induction of antiviral effector genes. Unlike RIG-I and MDA5, LGP2 lacks CARDs and then independent signaling activity through MAVS. LGP2 is known to enhance MDA5-...
The description of a pro-tumour axis between mouse IL-17-producing γδ T cells and pro-inflammatory and pro-angiogenic macrophages in an ovarian cancer mouse model. Article CAS PubMed PubMed Central Google Scholar Patin, E. C. et al. Type I IFN receptor signaling controls IL7-dependent ...
Such an increased proliferative response was also associated with augmented production (either at baseline or upon stimulation) of pro-inflammatory cytokines, including tumor necrosis factor (TNF), interferon gamma (IFNγ), interleukin-10 (IL-10), and IL-17 alpha (IL-17A) but not IL-6 (...