(A) Human pathways of Kyoto Encyclopedia of Genes and Genomes (KEGG) (80) are simultaneously plotted to show the most significant pathways in terms of Global Test p-value (vertical axis, shades of red) and impact (horizontal axis, circle diameter). The top 6 pathways that arise with low ...
In an attempt to identify potential signalling pathways involved in HGSOC survival, we used KEGG database to perform pathway analyses with both enrichment-based (hypergeometric test) and topological-based25 approaches. While the first approach tests if the amount of DEGs in a pathway is higher ...
e, f IPA of the differentially expressed genes (e) and KEGG pathway analysis of downregulated genes (f) upon C/EBPβ knockdown in C13* and SKOV3 cells. Arrows indicate P = 0.05. Negative z-scores (blue) represent the suppressed state of the function. g Scatter plot showing genome-...
These 23 genes have the potential to promote cisplatin resistance through various pathways, falling broadly into three categories: (1) promoting drug transduction, (2) enhancing DDR, and (3) regulating signal transduction to promote cell viability (Supplementary Figure 15). Consistent with these ...
Per-metabolite comparisons were made between cell lines and an interpretive analysis was carried out using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic library and the Ingenuity exogenous molecule library.We observed 288 identified metabolites, of which 179 were found to be ...
Gene signatures having positive or negative correlation with APE1/NPM1 were functionally characterized using the Cytoscape plugin ClueGO [79,80] querying the following functional and metabolic databases: CLINVAR_Human-diseases, WikiPathways, KEGG, CORUM-FunCat-MIPS, REACTOME (“Reactions” and “Pathway...
Differential analysis, GO, KEGG, GSVA and logistic regression models were performed by R. Survival analysis were applied to public databases. siRNA knockdown in A549, PC9, TE1 cell lines, qRT-PCR, western-blot, cck8 and EdU experiments were used for further verification in vitro.#485 genes ...
platinum drug resistance pathway. Consistently, DUSP5P1 overexpression in GC cells antagonized cytotoxic effect of Oxaliplatin, and shDUSP5P1 plus Oxaliplatin exerted synergistic effect on inhibiting GC metastasis in vitro and in vivo. DUSP5P1 depletion also suppressed the growth of platinum drug-...
9 and ‘non-responders’n =4, hereafter) at baseline (P < 0.01) with over-representation of these genes compared to T cells and other immune markers (with evaluable tumors from seven responders and nine non-responders) in cohort 1 (Fig.3A, Band Supplementary Table9). KEGG ...
To get more insights on the molecular pathway(s) that could drive apoptosis in SFPQ-silenced cells, we carried out a gene expression profiling (GEP) of MDAH and SKOV3 cells, silenced or not for SFPQ. Two KEGG-pathways were commonly enriched in both cell lines, namely the spliceosome and ...