Oncogenesis www.nature.com/oncsis ARTICLE OPEN DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance Xiaohong Wang1,2, Lianhai Zhang1, Qiaoyi Liang 2, Chi Chun Wong2, Huarong Chen 2, Hongyan Go
The JAK2/STAT pathway is hyperactivated in many cancers, and such hyperactivation is associated with a poor clinical prognosis and drug resistance. The mechanism regulating JAK2 activity is complex. Although translocation of JAK2 between nucleus and cyto
]. Oxaliplatin (OXA), a third-generationplatinum compoundintroduced in clinics, showed excellent anti-advanced HCC activity with tolerable toxicity. However, the overall effectiveness of platinum-baseddrug therapiesis limited by their tumor cell resistance, which often develops and causes patients to bec...
Novel mechanisms of platinum drug resistance identified in cells selected for resistance to JM118 the active metabolite of satraplatin Purpose The goal of this study was to identify molecular determinants of sensitivity and resistance to JM118, the active metabolite of satraplatin, ... G Samimi,S ...
In the following sections, we provide a background of platinum-based therapy and underlying drug resistance mechanisms and focus on potential clinical applications of liquid biopsies and treatment paradigms of platinum-resistant ovarian cancer. Access through your organization Check access to the full ...
Recent studies indicate that EMT accompanies the development of drug resistance to a number of cancer chemotherapies. The link between these two phenomena is still not elucidated, although several important molecules involved in both these complex processes, such as transcription factors (SNAIL, TWIST,...
Lack of a role for MRPI in platinum drug resistance in human ovarian cancer cell linesSummary The level of expression of the multidrug resistance-... S Sharp,V Smith,S Hobbs,... 被引量: 0发表: 0年 Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug...
Platinum (Pt)-based anticancer drugs are the mainstay of treatment for solid cancers. However, resistance to Pt drugs develops rapidly, which can be caused
cancers. However, resistance to Pt anticancer drugs develops rapidly upon their administration, which can be caused by overexpression of multidrug resistance transporters, activation of DNA repair mechanism, glutathione conjugation, and de- fect in cell cycle arrest induction by the drug [1–3]. Nove...
Small cell lung cancer accounts for 15% of all lung cancers. It occurs particularly in elderly men and smokers and is prone to involve early distant metastasis.1 Many patients with small cell lung ...