The JAK2/STAT pathway is hyperactivated in many cancers, and such hyperactivation is associated with a poor clinical prognosis and drug resistance. The mechanism regulating JAK2 activity is complex. Although translocation of JAK2 between nucleus and cyto
Summary The level of expression of the multidrug resistance-associated protein (MRP1) in a panel of human ovarian carcinoma cell lines and their variants with acquired cisplatin resistance was determined using Western blotting. No overexpression of MRP1 was detected in any of the cell lines. In ...
A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental imaging to the mapping of CT biodistribution after therapy in residual colorectal cancer and achieve a comprehensive analysis of the genet...
Platinum (Pt)-based anticancer drugs are the mainstay of treatment for solid cancers. However, resistance to Pt drugs develops rapidly, which can be caused
]. Oxaliplatin (OXA), a third-generationplatinum compoundintroduced in clinics, showed excellent anti-advanced HCC activity with tolerable toxicity. However, the overall effectiveness of platinum-baseddrug therapiesis limited by their tumor cell resistance, which often develops and causes patients to bec...
cancers. However, resistance to Pt anticancer drugs develops rapidly upon their administration, which can be caused by overexpression of multidrug resistance transporters, activation of DNA repair mechanism, glutathione conjugation, and de- fect in cell cycle arrest induction by the drug [1–3]. Nove...
In the following sections, we provide a background of platinum-based therapy and underlying drug resistance mechanisms and focus on potential clinical applications of liquid biopsies and treatment paradigms of platinum-resistant ovarian cancer. Access through your organization Check access to the full ...
Given the central role of drugs in the clinic, it is critical to overcome resistance by bypassing the barrier to significantly increase the concentration enough to inhibit the proliferation of -resistant . Therefore, rational design of appropriate nanoscale drug delivery platforms (nDDPs) loaded with...
Breast cancer (BC) is a significant cause of cancer-related deaths among women worldwide. Hypoxia, a common feature of solid tumor, is associated with drug resistance and a poor prognosis in BC. In this study, we present a strategy to overcome hypoxia-in
OBJECTIVE: To evaluate the efficacy of taxane and platinum-based chemotherapy guided by extreme drug resistance assay (EDRA) in patients with epithelial ovarian cancer. METHODS: Thirty-nine patients were enrolled, who were diagnosed as epithelial ovarian cancer, tubal cancer or primary peritoneal carcin...