These transporters seem to be contributed to cisplatin resistance through the reduction of drug accumulation in the cell. Better understanding the mechanism of cisplatin resistance associated with transporters will provide the useful informations for overcoming the cisplatin resistance. 展开 关键词:...
platinum drug resistance pathway. Consistently, DUSP5P1 overexpression in GC cells antagonized cytotoxic effect of Oxaliplatin, and shDUSP5P1 plus Oxaliplatin exerted synergistic effect on inhibiting GC metastasis in vitro and in vivo. DUSP5P1 depletion also suppressed the growth of platinum drug-...
Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecul...
Lack of a role for MRPI in platinum drug resistance in human ovarian cancer cell linesSummary The level of expression of the multidrug resistance-... S Sharp,V Smith,S Hobbs,... 被引量: 0发表: 0年 Substrates and inhibitors of human multidrug resistance associated proteins and the implicatio...
A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental imaging to the mapping of CT biodistribution after therapy in residual colorectal cancer and achieve a comprehensive analysis of the genet...
Given the central role of drugs in the clinic, it is critical to overcome resistance by bypassing the barrier to significantly increase the concentration enough to inhibit the proliferation of -resistant . Therefore, rational design of appropriate nanoscale drug delivery platforms (nDDPs) loaded with...
With the aim of developing a new generation of Pt(II)-based anticancer agents in response to the challenges of oxaliplatin-induced drug resistance, we performed a systematic screening of new Pt(II)-complexes with a quantitative structure–activity relationship (QSAR) study based on their ...
Article: Establishment of cis-diamminedichloroplatinum (II): Resistant human testicular seminoma cell line JKT/DDP and analysis of the expression o
Platinum (Pt)-based anticancer drugs are the mainstay of treatment for solid cancers. However, resistance to Pt drugs develops rapidly, which can be caused
Resistance is futile: A platinum(IV) prodrug conjugated to a gold-nanorod-based delivery agent avoids the type of drug resistance that is associated with cisplatin (see picture). This conjugate is taken up into cells through endocytosis, thus avoiding the resistance-associated uptake mediated by th...