Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecul...
Given the central role of drugs in the clinic, it is critical to overcome resistance by bypassing the barrier to significantly increase the concentration enough to inhibit the proliferation of -resistant . Therefore, rational design of appropriate nanoscale drug delivery platforms (nDDPs) loaded with...
aHPFS 8650 has a much greater laser resistance at 193nm versus the standard compaction curve HPFS 8650有更加伟大的laser抵抗在193nm对标准击实曲线[translate] asandy beige 浅褐色[translate] a它们是两个北京奥运会的主体育馆。 They are two Beijing Olympic Games' main stadium.[translate] ...
With the aim of developing a new generation of Pt(II)-based anticancer agents in response to the challenges of oxaliplatin-induced drug resistance, we performed a systematic screening of new Pt(II)-complexes with a quantitative structure–activity relationship (QSAR) study based on their ...
。 Second generation of platinum metals anti-cancer drugs--not only maintained a first-generation Platinum metallic drugs carboplatin tumor resistance spectrum of broad, and has the advantage of better therapeutic effect of solid tumors, significantly reduce the toxicity to the kidneys, nervous syste ...
platinum drug resistance pathway. Consistently, DUSP5P1 overexpression in GC cells antagonized cytotoxic effect of Oxaliplatin, and shDUSP5P1 plus Oxaliplatin exerted synergistic effect on inhibiting GC metastasis in vitro and in vivo. DUSP5P1 depletion also suppressed the growth of platinum drug-...
A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental imaging to the mapping of CT biodistribution after therapy in residual colorectal cancer and achieve a comprehensive analysis of the genet...
1) 产品编码: 1750; 2) 英文名称: Standard Platinum Resistance Thermometer; 3) 中文名称: 标准铂电阻温度计; 4) 包装: each 公司简介 上海甄准生物科技有限公司(简称甄准)专业提供科研试剂产品,主要包括高端化学试剂、生物学试剂、分析标准品、对照品、标准物质等,应用覆盖药物分析领域、食品安全领域、聚合物研究...
Establishment of cis-diamminedichloroplatinum (II) : Resistant human testicular seminoma cell line JKT/DDP and analysis of the expression of the genes related to anticancer drug-resistance associated with cytoplasmic CDDP metabolism Home > Section...
Platinum (Pt)-based anticancer drugs are the mainstay of treatment for solid cancers. However, resistance to Pt drugs develops rapidly, which can be caused