Oncogenesis www.nature.com/oncsis ARTICLE OPEN DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance Xiaohong Wang1,2, Lianhai Zhang1, Qiaoyi Liang 2, Chi Chun Wong2, Huarong Chen 2, Hongyan Go
In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been estab... Jones,Siracky,L R,... - 《British Journal of Cancer》 被引量: 60发表: 1993年 Acquisition of platinum drug resistance and platinum...
The JAK2/STAT pathway is hyperactivated in many cancers, and such hyperactivation is associated with a poor clinical prognosis and drug resistance. The mechanism regulating JAK2 activity is complex. Although translocation of JAK2 between nucleus and cyto
Although many cancers initially respond well to those drugs, drug resistance occurs frequently and different molecular mechanisms have been associated with it. However, predictive biomarkers of cellular response in specific tumour types still do not exist. Epithelial–mesenchymal transition (EMT) is a ...
The resistance of gliomas to platinum drugs is the result of a combination of influencing factors. Decreased intracellular drug concentration, enhanced function of cell processing active products, enhanced repair ability of cellular DNA damage, and blockage of related apoptosis pathways play an important...
Platinum (Pt)-based anticancer drugs are the mainstay of treatment for solid cancers. However, resistance to Pt drugs develops rapidly, which can be caused
In the following sections, we provide a background of platinum-based therapy and underlying drug resistance mechanisms and focus on potential clinical applications of liquid biopsies and treatment paradigms of platinum-resistant ovarian cancer. Access through your organization Check access to the full ...
cancers. However, resistance to Pt anticancer drugs develops rapidly upon their administration, which can be caused by overexpression of multidrug resistance transporters, activation of DNA repair mechanism, glutathione conjugation, and de- fect in cell cycle arrest induction by the drug [1–3]. Nove...
1) 产品编码: 1750; 2) 英文名称: Standard Platinum Resistance Thermometer; 3) 中文名称: 标准铂电阻温度计; 4) 包装: each 公司简介 上海甄准生物科技有限公司(简称甄准)专业提供科研试剂产品,主要包括高端化学试剂、生物学试剂、分析标准品、对照品、标准物质等,应用覆盖药物分析领域、食品安全领域、聚合物研究...
Small cell lung cancer accounts for 15% of all lung cancers. It occurs particularly in elderly men and smokers and is prone to involve early distant metastasis.1 Many patients with small cell lung ...