The rate of major adverse cardiovascular and cerebrovascular events was 12.8% (188/1,473) in the Q1 group, 12.8% (196/1,529) in the Q2 group, 15.1% (228/1,507) in the Q3 group, and 16.3% (150/1,537) in the Q4 group (P=0.010). The rate of major adverse cardiovascular events...
Bessman JD, Williams LJ, Gilmer PR (1981) The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Path 76:289–293 PubMedCASGoogle Scholar Cameron HA, Philips R, Ibbotson RM, Carson PHM (1983) Platelet size in myocardial infarction...
40]. Initial platelet adhesion to the blood vessel wall under high-shear stress is achieved by the binding of the (GP)Ib-IX-V complex on platelet cell surface to von Willebrand factor (vWF) expressed on endothelial cells and
We conducted a systematic literature review and analysis of the role of PEVs in tumourigenesis. Here, we summarise the mechanism of action of PEVs in regulating tumourigenesis and tumour progression, we summarise the application of PEVs and their derivatives in anti-tumour therapy, we present an ...
platelet count and increased survival post encephalomyocarditis virus infection [75]. Moreover, a mice model with this mutation exhibits severe thrombocytopenia, indicating platelet activation. A family with severe and early-onset SLE has been shown to have a gain-of-function mutation in theTLR7gene...
i, Platelet count of triacsin C-treated, FSG67-treated or vehicle-treated mice (n = 9). A two-sided t-test was used for statistical analysis (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001). Source data Full size image These results could also be translated into in ...
Genetic approaches have provided information on multiple genes related to normal haemostasis, such as those encoding receptors and signalling or secretory proteins, that determine platelet count and/or responsiveness. As highly responsive and secretory cells, platelets can alter the environment through the...
Splenectomy improved, but did not correct the platelet count to normal. It remained between 100 000 and 125 000/mm3. Most of his platelets retained the large agranular appearance noted before splenectomy, but a small percentage were of normal size and contained some granules. Since his mean...
Platelets are a significant component of the cell population in the tumour microenvironment (TME). Platelets influence other immune cells and perform cross-talk with tumour cells, playing an important role in tumour development. Extracellular vesicles (E
Autologous platelet transfusion was administered if the platelet count dropped below 10 × 109/L. Group B: Patients received transfusions of platelets collected before chemotherapy. The transfusion was performed when significant thrombocytopenia or bleeding symptoms occurred during or after chemotherapy....