16. This investigation was supported in part by Re- search Grant H D 00405, AM 10866, and Training Grant AM 5331 from the United States Public Health Service. The work was performed under the tenure of a USPHS Research Fellowship Grant AM 33-182, Dr. CONWAYa,nd a Lederle Medical ...
ArticleCASPubMedGoogle Scholar McLachlan, R. I., Rajpert-De Meyts, E., Hoei-Hansen, C. E., de Kretser, D. M. & Skakkebaek, N. E. Histological evaluation of the human testis--approaches to optimizing the clinical value of the assessment: mini review.Hum. Reprod.22, 2–16 (2007)....
All participants gave written informed consent prior data collection. The UK Biobank has ethical approval from the National Research Ethics Service (Ref 11/NW/0382). Consent for publication Not applicable. Competing interests The authors declare no competing interests.Additional...
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Image acquisition was performed on a Zeiss GeminiSEM 450 with 3View from Gatan (DigitalMicrograph Version 3.51.3720.0; SmartSEM version 6.06 with Service Pack 4), with the program SBEM Image (2021.08.dev) installed for controlling the acquisition91. For image acquisition an acceleration voltage of...
We may assume that in ME/CFS, inflammation may induce changes in the packing of specific cytokines/chemokines into selective EVs and that their release is intimately linked to the state of the releasing cells, healthy versus diseased, near or at a distance. We further analyzed cytokine-cytokine...
Next-generation genotype imputation service and methods. Nat Genet. 2016;48(10):1284–7. Article CAS PubMed PubMed Central Google Scholar The 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature. 2015;526(7571):68–74. Chang CC, Chow CC, Tellier L, ...
The failure of TBCs is influenced by a complex combination of service environment conditions and external mechanical loading, making it challenging to identify a single cause or mechanism of failure. Further research is needed to accurately determine the reasons for TBC failure. 4. Conclusions From ...
Alzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CLU) and complement receptor 1 (CR1), recognised as key
Studies that focus currently on exome content alone and have included variants of intermediate and low frequency have, however, reported larger genetic effects at lower MAF9–11. This type of work is relevant given that variants of large effect sizes have been suggested to segregate in ...