anti-protein C antibodyThe most novel finding was a significant elevation of anti-protein C antibodies and anti-protein S antibodies in the TC group (i.e., in patients on MHD with thrombosis of vascular access). It indicates that other pathogenetic mechanisms in addition to endothelial damage ...
Based on protein annotations in the Human Protein Atlas (https://www.proteinatlas.org)12, 78% were annotated as secreted, 14% as membrane bound, and 8% as exclusively intracellular (Supplementary Data3). Based on data from the Genotype-Tissue Expression (GTEx) project13, tissue expression var...
seeAppendix Table II). The normal totalplasma proteinconcentration ranges from5.5-8.9gm/dlin domestic animal species, and it is a complex mixture includingsimple proteins,glycoproteins(Chapter 20), and variouslipoproteins(Chapter 63). Thousands ofantibodies(immunoglobulins) are also present in plasma, ...
Neutralizing antibodies against therapeutic proteins can be potentially harmful if the antibody blocks not only the therapeutic activities of the therapeutic protein but also the normal functions of the endogenous counterpart. Detection of the neutralizing anti-therapeutic protein antibodies generally relies on...
Matrix metalloproteinase 9 (MMP-9), also known as gelatinase B with a molecular weight of 92 kDa, belongs to the MMP family of 24 zinc-dependent endopeptidases that is involved in the breakdown of extracellular matrix. The regulation of the MMP occurs at gene transcription, protein translation...
Proteins that may be involved in two types of actin-membrane association are discussed. The first set includes $\alpha$-actinin, vinculin, fimbrin and a new cytoskeletal protein that are all concentrated in adhesion plaques, those regions of cultured fibroblasts where bundles of actin microfilaments...
20-22 They add weight to the hypothesis that reduction of amyloid by anti-Aβ antibodies could have downstream effects consistent with disease modification and suggest that fluid biomarkers could have a role in monitoring response to treatments (at least as a group measure of target engagement/...
(see above) and photoreceptors [8]. The mapping of CD133 to differentiated epithelial cells using LacZ reporter-based mice further contributed to the debate [76]. The use of alternative antibodies against human CD133 has confirmed its wide protein expression [11,17,21,24], similar to that ...
As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based ri
It is also important to bear in mind some limitations in our study. First, the antibodies used in the measurements of the protein levels (see Methods section) bind to a short stretch of amino acids in the target protein. Hence, there is a possibility that missense variants are giving rise...