Plasma cellsBy combining single-cell mRNA sequencing and a genetic pulse–chase mouse model, we identified multiple subsets of mouse long-lived plasma cells and showed that these cells can originate from diverse developmental routes.doi:10.1038/s41590-022-01346-4...
Since they also retain a high NP-binding capacity up to 180 days post- immunization (Fig. 1b), it is unlikely that they originate from a long-lasting ongoing TI immune response. BM plasma cells induced by NP-dextran express a functional BCR. To determine whether membrane-bound Igs ...
Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune responses. In tumour-associated tertiary lymphoid structures, T cells and B cells interact and under
2. Who? – The origin of plasma cells 2.1. The origin of B-cells B-cells originate in the bone marrow from hematopoietic stem cells (summarized in [26]). B-cell lymphopoiesis involves rearrangements of variable, diversity and joining genes that leave every B-cell with a unique B-cell rec...
It is characterized by high levels of plasma cells circulating in peripheral blood. PCL may originate de novo (primary PCL) or as a secondary transformation of MM (secondary PCL). The incidence of PCL in Europe has been estimated at 4 cases/10 000 000 persons/year. Secondary PCL ...
Inter-region, Inter-sector Plasma separated from whole blood most often by manual centrifugation or by apheresis. The priority for the blood collected is usually for the production of red blood cells. However, the plasma can be suitable for further manufacture of biotherapeutics and transfusion. The...
State True or False. Clathrin forms "cages" on vesicles that originate from plasma membrane. In the tight junction, the lipid portion of the cell membranes are tightly bound together by interlocking membrane proteins. (a) True (b) False ...
When B cells are activated, they differentiate into: a) plasma cells. b) memory B cells. c) both a and b. d) None of the above. What is the cell from which all blood cells originate? What supportive cells are found between the capillaries? What do enteroendocrine cells secrete? What ...
Deciphering the mechanisms by which cells control the lateral and transversal membrane organization is of general interest considering that auto-immune, atherogenic, or proliferative pathologies might originate from a dysfunction of the lipid equilibrium in the plasma membrane. This field of research is,...
Plasma Aβ is well known to originate in different organs and it also is known that Aβ binds to different proteins and cells in the blood, thereby possibly accounting for why plasma Aβ levels do not correlate with Aβ measured in CSF or CNS plaque burden measured by PET amyloid plaque ...