IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans . Gastroenterology (2011) 140 ( 3 ):947–5610.1053/j.gastro.2010.12.005 [ Cross Ref ]Barone F., Vossenkamper A., Boursier L., Su W., Watson A., John S., Dunn-Walters ...
IgG, and IgA. These cells originate from post-natal BM cells as early as 1 week after birth independently of exogenous antigens. In the presence of copious amounts of IL-4 from NKT2 cells, IgE+PCs also developed. Single-cell RNA sequencing (scRNA-seq) paired...
These observations strongly suggest that lymphoma cells and plasma cells originate from the same clone, and that plasma cells, as well as lymphoma cells, which have undergone class switch recombination, could produce IgG type M-protein in this case....
Increased levels of cfDNA have been reported in patients with cancer of breast, cervix, colon, liver and it was shown that cfDNA can originate from both tumour and non-tumour cells.Objectives: Levels of cfDNA of a large series of children with lymphoma were evaluated and analyzed in relation ...
Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune responses. In tumour-associated tertiary lymphoid structures, T cells and B cells interact and under
The reticuloendothelial cells of the liver are in charge of plasma protein synthesis in adults. The bone marrow, degenerating blood cells, general body tissue cells, and the spleen also contribute to the formation of plasma proteins. Gamma globulins originate from B lymphocytes, which in turn fo...
plasma membrane- a thin membrane (a double layer of lipids) enclosing the cytoplasm of a cell; proteins in the membrane control passage of ions (like sodium or potassium or calcium) in and out of the cell; "all cells have a cell membrane" ...
miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms - ScienceDirect Chromosome 13q deletion [del(13q)], harboring the miR-15a/16-1 cluster, is one of the most common genetic alterations in mature B-cell malignancies, which originate from germinal cen...
In myeloma, most of the abnormal plasma cells remain in the bone marrow and are not found in the peripheral blood. In PCL, the abnormal plasma cells are in the peripheral blood. Therefore, PCL is considered to be an advanced form of myeloma. PCL can either originate as the primary manifes...
Since they also retain a high NP-binding capacity up to 180 days post- immunization (Fig. 1b), it is unlikely that they originate from a long-lasting ongoing TI immune response. BM plasma cells induced by NP-dextran express a functional BCR. To determine whether membrane-bound Igs ...