Long-lived plasma cells (LLPC) may survive for years to decades. Such long-lived plasma cells are also responsible for producing pathogenic antibodies that cause a variety of challenges such as autoimmunity, allograft rejection, and drug neutralization. Up to now, various therapeutic strategies ...
cells are enriched with high inflammation, IFNG, IgG expression, and self-identified Black race (a–d). Dashed horizontal and vertical lines indicate the median for tertiary lymphoid structure activity and plasma cells, respectively.χ2P-values are all two-sided. Abbreviation: IFNG interferon gamma...
Long-lived plasma cells are generated in mucosal immune responses and contribute to the bone marrow plasma cell pool in mice During systemic immune responses, plasma blasts are generated in secondary lymphoid organs and migrate to the bone marrow, where they can become long-lived, being responsible...
For example, tumors from smokers had elevated plasma cells and decreased B-cell clonality compared with those of non-smokers. Further, lung tumors withEGFRmutations had lower levels of plasma cells and higher levels of less-differentiated B cells when compared to those withKRASor other mutations. ...
Syntaxin-4 is implicated in the secretion of antibodies by human plasma cells PCs are responsible for the production and secretion of antibodies, the effector molecules of the humoral immune response. The molecular mechanisms respons... - 《Journal of Leukocyte Biology》 被引量: 0发表: 2014年 ...
plasma cells areCD19+andCD20−. Abnormal plasma cells are CD19−and CD20−. These cells are typically also CD56+. Up to 20% of cases of neoplasticplasma cell neoplasmsareCD117+. If neoplastic plasma cells are negative for CD56, CD27, or CD45, it is thought to impart a worse ...
4, 5, 8 At present, the origin of plasma PAI-1 is not known, but it is most likely that endothelial cells and/or liver are responsible for plasma PAI-1 production.5 Platelet PAI-1 is present in α granules.9 Recently, much attention has been given to the role of PAI-1 in the ...
Plasma cells synthesize View Solution [A]: B-cells are responsible for antibody me- diated immunity which directly recognize an antigen and give rise to antibody secreting plasma cells and memory 8-cells. [R]: Immunity can be induced by using vac- cines for long- lived active period. ...
Higher- or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC recycling, respectively; however, how commitment to the plasma cell fate takes place is unclear. We found that a population of light zone (LZ) GC cells, Bcl6loCD69hi expressing a transcription...
Even after a 4-h incubation with the blood cells no significant (p ≤ 0.05) difference could be measured (Fig. 14). This leads to the conclusion that plasmatic and non-cellular components in the blood are responsible for endotoxin neutralization. Figure 14 Influence of leucocytes on ...