Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside in the bone marrow (BM). However, due to LLPC rarity, it has not been possible to define their phenotypes or determine their heterogeneity. By single-cell mRNA sequencing, cytometry and a genetic pulse...
Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the B cell phenotype. Furthermore, the isotype and specificity of the antibodies produced by plasma cells can drive distinct immune responses. Here we ...
This variability does not vanish when normalized by initial or average antibody levels (Figure 1A), indicating that it is not only due to differences in the number of plasma cells produced. The variability vanishes only when the decay curves are normalized by their logarithmic range (Figure 1B)...
CAP has tremendous applications in bioengineering and medicine. Physics of CAP and various plasma diagnostics are covered. Various effects related to interaction of the CAP with cells (cell migration, apoptosis, integrins activation etc) are considered. The therapeutic potential of CAP with a focus ...
Masson-Bessiere C, Sebbag M, Durieux JJ, Nogueira L, Vincent C, Girbal-Neuhauser E, Durroux R, Cantagrel A, Serre G (2000) In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and ...
In an immune response, which type of cells secrete antibodies? (a) Macrophages (b) Cytotoxic T-cells (c) Plasma cells (d) Helper T-cells. Humoral and Cellular Immunity: Acquired immunity is mediated by a specialized immune syste...
The beneficial effect of PRP on the meniscus repair failure rate is supported by prior basic science research, because an in vitro and animal study of PRP found the therapy to increase the concentration of various growth factors and upregulate the viability of meniscal cells [8, 14, 39]. Many...
Why can stem cells become any type of cell? How do antibodies know to attack antigens? How are cells in the epidermal tissue adapted? List the type of cells that can be produced by blood stem cells. Describe the production of red blood cells. ...
Age-matched naive cohorts served as control for natural IgM cells. Natural IgM cells produce natural IgM antibodies, which are constantly present in the serum and provide an early, polyreactive response against pathogens12. To assess longevity, we first immunized mice with hydroxy-3-nitrophenyl...
cells are enriched with high inflammation, IFNG, IgG expression, and self-identified Black race (a–d). Dashed horizontal and vertical lines indicate the median for tertiary lymphoid structure activity and plasma cells, respectively.χ2P-values are all two-sided. Abbreviation: IFNG interferon gamma...