Protein electrophoresis (PEL) and immunofixation electrophoresis (IFE) assays form the hub of laboratory testing for multiple myeloma and related plasma cell proliferative diseases. The secreted monoclonal proteins (M proteins) act as serological 'tumor' markers, and the electrophoretic assays identify M...
Summary The plasma cell disorders are a heterogeneous group of clonal plasma cell proliferations with clinical presentations that range from a completely asymptomatic laboratory finding to a highly aggressive malignant neoplasm. The correct diagnosis and classification of these diseases requires correlation of...
1). Those individuals complicated with other eye diseases or with severe impairment of liver, kidney or heart function were excluded from selection. Fig. 1 Inclusion and exclusion flowchart of the case-control study. NPDR, non-proliferative DR; NDR, non-DR; PDR, proliferative DR Full size ...
Light chain deposition disease (LCDD) and immunoglobulin light chain (AL) amyloidosis are uncommon, and heterogeneous clonal plasma cell (PC) proliferative disorders defined by the different biochemical characteristics of the underlying ... Luís,Rodrigues,Marta,... - 《Bmj Case Reports》 被引量: ...
Glomerular Diseases Due to Plasma Cell Dyscrasia Plasma cell dyscrasiais a condition characterized by abnormal synthesis of Ig molecules or subunits. Multiplemyeloma(MM) is the most advanced form of plasma cell dyscrasia, comprising 10% ofhematological cancers.123MM is defined by the presence of...
plasma and to evaluate the correlation of plasma concentrations of EBV DNA with the EBV genomic status in peripheral blood T-cells and neoplastic cells and with the clinical outcome of patients with peripheral T-cell and NK-cell lymphomas (PTCL) and peripheral T-cell proliferative diseases (PTPD...
In vitro cell culturePlatelet-rich plasmaPediatric surgeryTestis torsionUndescended testis and testicular torsion represent two frequent andrological diseases that affect the pediatric age. Despite these testicular disorders having different causes, they both negatively influence fertility in adulthood mainly ...
Three plas- ma cell myelomas aberrantly expressed CD56 or Cyclin D1. One of the six cases was positive for both CD56 and Cyclin D1. All cases were negative for Cyclin D3. With Ki-67/CD138 immunohistochem- ical double staining, the proliferative fraction of the plasma cells ranged from ...
(COVID-19) ARDS phenotype. The effects of imatinib could also implicate a beneficial effect for the treatment of diseases with increased vascular remodelling such as pulmonary arterial hypertension (PAH). Imatinib modulated a substantial number of proteins that are taking part in the pathobiology of...
The application provides a method of identifying or monitoring a plasma cell associated disease, comprising purifying immunoglobulin free light chains (FLCs) from a sample from a su