(IL)-6, A proliferation-inducing ligand, and B-cell activating factor are provided by stromal cells and various hematopoietic cells, such as eosinophil.4–9 PCs can produce only a single kind of antibody in a single class of immunoglobulin, but each cell can produce several thousand antibodies...
Flow cytometry is also useful in the diagnosis of plasma cell dyscrasias. Plasma cells areCD38+(bright) and CD138+(although less sensitive). Plasma cells in the blood andtonsilsare CD45+, whereas in the bone marrow plasma cells may be either CD45+positive or CD45−. Normal plasma cells...
;浆细胞病(Plasma cell dyscrasias);隐性浆细胞病良性单克隆免疫球蛋白血症;继发性单克隆免疫球蛋白血症。病因:尚未完全明了可能与遗传有关,有染色体异常病毒感染继发于其他疾病(慢性骨髓炎、结核、慢性肝炎);M蛋白免疫球蛋白两条相似的重链和两条轻链组成,重链γαμδε,轻链κλ。免疫球蛋白IgG IgA IgM IgD ...
PLASMA cell dyscrasias refer to a spectrum of disorders characterized by the monoclonal proliferation of lymphoplasmacytic cells in the bone marrow and, sometimes, tissue deposition of monoclonal immunoglobulins or their components (Table 21-1). The disorders include multiple myeloma (MM) and Waldenstr...
Present clinical and laboratory diagnostic criteria permit a more accurate diagnosis and closer follow-up of patients with plasma cell dyscrasias. A ten-year follow-up of a group of 423 patients showed that the indications for and the adjustment of treatment are more precise when these criteria ar...
Plasma cell dyscrasias (PCDs) are a group of clonal disorders characterized by the uninhibited expansion of a monoclonal population of malignant plasma cells. Plasma cells arise from B cells in the bone marrow and produce immunoglobulins that constitute the body's normal humoral immune response. The...
Plasma cell leukemia (PCL) is an uncommon but aggressive malignancy that accounts for 1–2% of all plasma cell dyscrasias. First described in the early 1900s, PCL has been defined as the presence of ≥ 20% circulating plasma cells (CPCs) on conventional white blood cell differential count...
Serum-free light-chain analysis in diagnosis and management of multiple myeloma and related conditions The introduction of the serum-free light-chain (S-FLC) assay has been a breakthrough in the diagnosis and management of plasma cell dyscrasias, particularl... P Milani,G Palladini,G Merlini -...
plasma cell noun Synonyms for plasma cell nouna cell that develops from a B lymphocyte in reaction to a specific antigen Synonyms plasmacyte Related Words lymph cell lymphocyte plasmablast Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. ...
The tropism of organ involvement in primary systemic amyloidosis: contributions of Ig VL germ line gene use and clonal plasma cell burden Monoclonal gammopathy of undetermined significance, waldenstrom macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatment. Mayo ......