近日,扬州大学农学院张韬教授课题组在Molecular Plant在线发表了题为PDLLMs: A group of tailored DNA large language models for analyzing plant genomes的研究论文,开发了一系列基于植物基因组的基础DNA大语言模型,该研究构建的130M大小的plant DNAMamba模型仅以十分之一的参数量就打败了由InstaDeep、Google DeepMind...
Sex determination systems in plants have evolved many times from hermaphroditic ancestors (including monoecious plants with separate male and female flowers on the same individual), and sex chromosome systems have arisen several times in flowering plant evolution. Consistent with theoretical models for th...
Biotic homogenization is primarily driven by native species’ extirpation and the introduction and spread of non-native species, commonly due to human activity11,12,13. The balance and influence of these contributing factors remains largely untested across different scales. For thousands of years, ...
DNA was extracted using the Qiagen DNeasy kit. For O. secunda, 206 individuals were sequenced for the chloroplast trnS-trnG intergenic spacer, 154 individuals were sequenced for the nuclear internal transcribed spacer (ITS) region, and 218 individuals genotyped for five nuclear microsatellite loci. ...
However, the mechanisms underlying the pro-proliferative effects of many PDNVs remain unknown. It is important to note that the impact of PDNVs on cell proliferation is influenced by the source of nanovesicles [56]. Cabbage-derived nanovesicles were found to promote the proliferation of human ...
Common wheat (Triticum aestivumL.) provides nearly 20% of the global supply of calories and carbohydrates for human consumption [1,2]. The productivity of this crop is challenged by several threats like human activities, climatic change, and unfavorable environmental conditions [3,4]. Soil salinit...
Transcription factors are usually composed of at least four discrete domains: a DNA-binding domain, a nuclear-localization signal, a transcription-activation domain, and an oligomerization site. These domains operate together to regulate many physiological and biochemical processes, and to activate and/...
DNA for SNP genotyping was extracted for each accession from bulked leaf samples of eight 2-weeks old seedlings. A customized oligonucleotide pool assay (IPK-OPA, unpubl) containing 1536 allele specific oligos was used to genotype the panel by Illumina's GoldenGate technology (Illumina, San Diego...
RNA silencing is a central regulator of gene expression in most eukaryotes and acts both at the transcriptional level through DNA methylation and at the post-transcriptional level through direct mRNA interference mediated by small RNAs. In plants and invertebrates, the same pathways also function direc...
we usedAgrobacterium-mediated DNA delivery inNicotiana benthamianaas a transient gene expression platform. This allowed for production of3and4as substrates and the combinatorial testing of selected gene candidates (Methods). We were unable to identify an oxidase that could act directly on4, so we in...