In the first area, the major topics of concern are the entry and possible storage of substances in placental cells and through the placenta, which is aided perhaps by various transporters and efflux pumps, the distribution and binding of compounds in placental cells, and the biotransformation of ...
First, it may be more resistant to the transient changes in gene expression associated with labor and delivery,12–14 as well as the effects of placental storage before sample processing.15 Although we did in this case observe an inverse association between TIMP3 methylation and expression, ...
Yes, however nature has intended for your placenta to be consumed as soon as possible after birth so we believe 'the sooner the better’. We advise you read the storage guidelines above. Keep your placenta below 8°C after birth using ice packs and cooler bag for no longer than 12 hours...
the placenta+decidua responds with phosphorylative action already at 2 h, before regulation of gene expression at 5 h, indicative of an acute response not immediately visible at the mRNA expression
The utilization of primary placental cells is also constrained by ethical concerns regarding tissue availability, storage, and manipulation. Lately, human trophoblast stem cells (hTSCs) have been isolated from blastocyst trophectoderm or first-trimester placenta (Okae et al., 2018), demonstrating the ...
In both types of experiments, no retinyl esters were detected in the culture medium, suggesting that retinyl esters were produced for storage purpose. These results suggest that villous mesenchymal fibroblasts are primary sites of retinol esterification and storage in the placenta. (Pediatr Res 48: ...
Following removal of the maternal and fetal surfaces, the sample was washed twice in cold PBS (phosphate-buffered saline), placed in liquid nitrogen and transported to the laboratory for storage at −80 °C. To reduce confounding by differences in gestational age, we included in our study ...
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These enzymes determine bioactive lipid signaling, supply, and storage through the generation or degradation of lipids and fatty acids, respectively. This review focuses on the role of lipid-metabolizing serine hydrolases during normal pregnancy and in pregnancy-associated pathologies, such as preeclampsia...