Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part I: Ethical & scientific issues. Ann Inter Med, 2000; 133(6):455-463.Temple R, Ellenberg SS. Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical ...
2000. Placebo-controlled trials and active-control trials in the evaluation of new treatments: Part 1: Ethical and scientific issues. Annals of Internal ... R Temple,SS Ellenberg - 《Annals of Internal Medicine》 被引量: 0发表: 2000年 The ethics of placebo-controlled trials Comment in N Eng...
Active-control trials: How would a new agent compare with placebo? A method illustrated with clopidogrel, aspirin, and placebo Background In an active-control trial with a new treatment and a comparator that has placebo-controlled trials, how might the effect of the new therapy ver... LD ...
A phase 3, multicenter, double-blind, three-arm, randomized, placebo- and active-controlled, multiple-dose, parallel-group study was conducted to evaluate the efficacy and safety of 50 mg IV tramadol versus placebo and 4 mg IV morphine over 48 h in patients with postoperative pain following a...
Interferon and amantadine in naive chronic hepatitis C: A double‐blind, randomized, placeboヽontrolled trial Recent controlled trials on the efficacy of an amantadine/interferon combination in treatment-naive patients with chronic hepatitis C yielded contradictory... B Helbling,I Stamenic,F Viani,....
In the present study, we report the results of a K-877 phase 2 study in dyslipidaemic patients with high TG and low HDL-C levels. 2. Methods 2.1. Patients/study design and participants We undertook this randomized, double blind, active- and placebo-controlled phase 2 trial at 19 sites...
We assessed the dose-response relationship of cagrilintide regarding the effects on bodyweight, safety, and tolerability. METHODS :We conducted a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial at 57 sites including hospitals, specialist ...
psychotherapyintheabsenceofcontrolledtests.There arenoprospective,randomized,controlledtrials,toour knowledge,ofpsychotherapyforatypicaldepressionor ofcognitivetherapycomparedwithamonoamineoxi- daseinhibitor.Sincethereisonly1placebo-controlled trialofcognitivetherapy,thistrialfillsagapinthelit- eratureonpsychotherapyfor...
The inclusion of active comparators in regulatory trials should not be seen as an alternative, but as a useful complement to the information that can be obtained from placebo-controlled studies. 展开 关键词: Placebo Non-inferiority Methodology Psychopharmacology ...
The MAPTRx doses evaluated in this study achieved the target t-tau reduction of ~50%, but determining whether this reduction is efficacious will require further evaluation in larger, well-controlled trials. Similarly, MAPTRx-treatment related effects on exploratory biomarkers will require further ...