PKR inhibits translation initiation through phosphorylation of the α subunit of the initiation factor eIF2 (eIF2α) and also controls the activation of several transcription factors, such as NF-κB, p53, and the Stats. In addition, PKR mediates apoptosis induced by many different stimuli, such ...
Rabbit polyclonal PKR antibody,PKR抗体,PKR antibody 应用类型 IHC 免疫原 PKR antibody was raised in Rabbit using the peptide sequence around phosphorylation site of threonine 451 (K-G-T(p)-L-R) derived from Human PKR as the immunogen.
PKR Antibody: The interferon-inducible, double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family, possessing serine-threonine kinase activity and two dsRNA-binding motifs
Antibody 克隆号 SY230 抗原 Synthetic phospho-peptide corresponding to residues surrounding Thr446 of Human PKR aa 421-470 查看免疫原 偶联物 Unconjugated 形式 Liquid 浓度 1 mg/mL 纯化类型 Protein A 保存液 TBS, pH 7.4, with 40% Glycerol, 0.05% BSA 内含物...
The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr446. AA range: 413-462. Specificity: Phospho PKR (Thr446) Polyclonal Antibody detects endogenous levels of PKR protein. only when phosphorylated at Thr446. ...
DNA-templatedtranslationprotein phosphorylationnegative regulation of cell proliferationresponse to mechanical stimulusresponse to virusresponse to toxic substanceregulation of translational initiation by eIF2 alpha phosphorylationnegative regulation of translationpeptidyl-tyrosine phosphorylationevasion or tolerance by vi...
The interferon (IFN)-induced PKR mediates inhibition of protein synthesis through phosphorylation of the alpha subunit of eukaryotic inititation factor 2 (elF2alpha) and is also involved in the induction of the IFN gene through the activation of the transcription factor NF-kappa B. ...
Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. Saelens, X, et al. (2001) J. Biol. Chem., 276: 41620-8 (2001) Species Reactivity Key Applications Host Format Antibody Type H WB Rabbit Purified Polyclonal Antibody Description: Anti-phospho-PKR...
PKR/Eif2ak2 Rabbit Polyclonal Antibody (KO Validated) -20ºC保存,Western一抗稀释液-20ºC或4ºC保存,一年有效。Western一抗稀释液优先推荐4ºC保存,长期不使用可以考虑-20ºC保存,但冻融可能会导致出现轻微的浑浊和少量不溶物。 注意事项: ...
(PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the a subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2a...