The self-help PKD App informs and educates people who are newly diagnosed or at the early stages of polycystic kidney disease (ADPKD). Open the app and... -…
The researchers also noted that in rats, relaxin reduced the size of the large fluid-filled cysts that gradually encroach onkidney functionin human PKD patients. PKD was the first disease to be recognized as a ciliopathy, a disorder characterized by defects in primary cilia, tiny hair-like str...
1573 REGRESSION OF CONGENITAL MURINE POLYCYSTIC KIDNEY DISEASE (PKD) IN METANEPHRIC ORGAN CULTURE (MOC)A form of autosomal recessive PKD naturally occurs in the mutant CPK strain of C57BL/6J mice. In order to examine the role of enviromental factors in the expression of genetically determined PKD...
Polycystic kidney disease--PKD--is a genetic disorder characterized by the growth of multiple cysts in the kidneys. The kidneys filter wastes from the blood and play a role in regulating blood pressure and secreting hormones. Cysts are filled with fluid and can enlarge the kidneys, causing poor...
Patients with PKD develop cysts on the kidneys, which progressively increase in size and number. The kidneys become enlarged, eventually leading to kidney failure. Previous research has suggested that the buildup of fluid in the cysts is related to chloride secretion, which is affected by the CFT...
PKDREJ; polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin); polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin) like,polycystic kidney disease (polycysti Entrez Gene ID 10343 UniProt ID Q9...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder leading to end-stage renal failure in humans. In the PKD/Mhm(cy/+) rat model of ADPKD, the point mutation R823W in the sterile alpha motif (SAM) domain of the protei
MFF is the predominant DRP1 receptor in mammalian cells (Otera et al., 2010) and is highly expressed in tissues with high energy demands, such as heart, brain, muscle, kidney, and liver (Gandre-Babbe and van der Bliek, 2008). Knockdown of MFF results in elongated mitochondria, whereas ...
The size of each bubble is proportional to the sample size. Abbreviations: CRISP, Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease; eGFR, estimated glomerular filtration rate; HALT-PKD, HALT Progression of Polycystic Kidney Disease; STAGED-PKD, study to assess glucosylceramide ...
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited monogenic disorders, characterized by a progressive decline in kidney function due in part to the formation of fluid-filled cysts. While there is one FDA-approved therapy, it is associated with potential adverse...