(2007). PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Lett. 581, 4279-4287.Eiseler, T., Schmid, M. A., Topbas, F., Pfizenmaier, K., and Hausser, A. (2007) PKD is recruited to sites of actin remodelling at the ...
Immunoprecipitation of Vps34-FLAG pulled down endogenous Beclin 1 (Figure 5a), suggesting that overexpression of Vps34 is sufficient to induce the formation of the autophagy-regulating complex. Interestingly, we found that HA-PKD specifically co-immunoprecipitated with Vps34-FLAG but not with the ...
Interestingly, the interaction of PKD with MFF increased in nocodazole-arrested mitotic cells relative to cells in G2 and in interphase stage (Figure 4A). To address if the MFF interaction with PKD can induce MFF phosphorylation, we immunoprecipitated FLAG-MFF co-expressed with WT, constitutively ...
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited monogenic disorders, characterized by a progressive decline in kidney function due in part to the formation of fluid-filled cysts. While there is one FDA-approved th
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2 3 Franck Belibi*, Kameswaran Ravichandran*, Iram Zafar*, Zhibin He and Charles L. 4 Edelstein. 5 6 Division of Renal Diseases and Hypertension, Univ. of Colorado at Denver and the 7 Health Sciences Center, Aurora, Colorado, USA 8 9 *Authors contributed equally to the study 10 11 ...