目前为止,形成心肌肥厚的信号通路包括PKC、蛋白激酶B(Akt)、钙调神经磷酸酶(CaM)、丝裂原活化蛋白激酶MAPK、酪氨酸激酶受体gp130/STAT、牵拉敏感离子通道以及细胞骨架等。其中PKC途径是调控心肌细胞的生长、分化以及肥厚的过程中信号转导通路的关键环节。心肌细胞可通过Gq/PLC/Ca2+/PKC、PKC/MAPK、PKC/NF-κB等相关...
蛋白激酶水解三磷酸腺苷(ATP) 并将 ATP 末端磷酸基团 (PO4) 转移到多种氨基酸残基的羟基上，从而将蛋...
LI Yu-hua, HUANG Ling, WEI Xiao-hua, WEN Jin-hua, ZHONG Guo-ping, HUANG Min, BI Hui-chang. Regulation of P-glycoprotein gene expression by PKC/NF-κB-PXR signaling pathway [J]. Acta Pharmaceutica Sinica, 2017, 52(1): 51-57.
(2): 50582 乐志培等. 生物信息胞内传递分子机理. 世界图书出版, 19973 taylor ss. 依赖于camp的蛋白激酶. 国外医学分子生物学分册j. 1991, 13(1): 39404 乐志培. 蛋白激酶研究进展, 自然杂志j. 1999, 21(1): 1135 bjrn s s , kjetil t. specificity in the camp/pka signaling pathway . ...
Pathway Description Legend Protein kinase C (PKC) family members regulate numerous cellular responses including gene expression, protein secretion, cell proliferation, and the inflammatory response. The basic protein structure includes an N-terminal regulatory region connected to a C-terminal kinase ...
Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes. Additionally, stimulation of adipocytes with the exchange protein directly activated by cAMP (Epac) agonist did not induce IL-6 expression. Instead, the β... IE Tchivileva,ST Kai,M Gambarian...
Specificity in thecAMP/PKAsignaling pathway。differential expression,regulation,and subcellular localization of subunits of PKA,Frontiers in Bioscience[J]。2000,5:678-693 [6]林明群,张宗梁.蛋白激酶A(PKA)介导的信号通路正调节还是负调节?科学通报[J]。1999,44(17):1793-1804 [7]翟中和,王喜忠,丁明孝。
the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depletedin vivo, indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy. Being a pot...
PKC途径 以肌醇-1,4,5-三磷酸（inositol1,4,5-trisphosphate,IP3)和二酰甘油（1,2-diacylglycerol,DAG)作为双信使的磷脂酰基醇信号通路。PKC系统(proteinkinaseCsystem，PKCsystem)由于该系统中的第二信使是磷脂肌醇,故此这一系统又称为磷脂肌醇信号途经(phosphatidylinositolsignalpathway)。在这一信号转导途径...
ZK-H2566 人WNT1诱导信号通道蛋白2(WISP2)ELISA检测试剂盒 human WNT1 Inducible Signaling Pathway Protein 2 (WISP2) ELISA Kit 96T/48T ZIKER子科生物 ZK-H2567 人沉默调节蛋白1(SIRT1)ELISA检测试剂盒 human Sirtuin 1 (SIRT1) ELISA Kit 96T/48T ZIKER子科生物 ZK-H2568 人含硬化蛋白域蛋白1(SO...