Ka = [A-] [H+] / [AH] The equation above indicates the concentration of released protons (acid) in relation to the molecule concentration in the solution. Hence, Ka represents the strength of an acid and as this
balance and food intake13, the present study shows for the first time that FFAR1 signaling might also play an important role in mood disorders such as depression. There was a trend for the FFAR3 to increase with the consumption of an HFD, however, it did not reach statistical significance....
There was a significant cor- relation between the plasma concentrations of exisulind and gastrointestinal toxicities [413]. In addition, clinical trials demonstrated that tadalafil increased T-cell expan- sion, reduced peripheral MDSC and Tregs numbers, and enhanced tumor-specific immunity in response ...
To demonstrate how macroscopic pKa values computed this way relate to ST and PF results it is instructive to treat the simple example of a two-tautomer acid in equilibrium with a single-tautomer base, i.e. HA1 Ka,1 → A− + H+, HA2 Ka,2 → A− + H+ (8) for which Eq. (...
The current-voltage relation curves of L-type calcium channels showed no significant difference between adult WT and AC6ΔN/ΔN cardiomyocytes (Additional file 1: Figure S6a-b). No change in the expression level of calcium-handling proteins such as RyR, L-type calcium channel, and SERCA2 ...
The location of the PKA phosphorylation sites in relation to the Shp2 N-terminal (N) and C-terminal (C) SH2 domains and the PTP domain are shown in context of the structure of Shp2 (Fig. 3A). The hydroxyl group of the Thr-73 side chain participates in a helix-capping interaction wi...
The results of the molecular modeling investigations of these antiplatelets were compared to the available experimental structural data and discussed in relation to the present theories of action of these agents. Figure 1. Structure and atom labeling in the antiplatelet drugs investigated. 2. Results...
A. It is required of superiors, according to that power they receive from God, and that relation wherein they stand, to love, pray for, and bless their inferiors; to instruct, counsel, and admonish them; countenancing, commending, and rewarding such as do well; and discountenancing, ...
pKa是电离常数Ka的负对数。通常,酸性和碱性化合物均使用pKa。 对于酸性化合物∶ HA = H++A- pKa = -log10([H+]·[A-]/[HA]) 对于碱性化合物∶ HB+ = H++B pKa = -log10([H+]·[B]/[HB+]) 根据上述关系式,可得出酸性和碱性化合物的有用性质。
Next, we evaluated CREB transcriptional activity in relation to YAP levels. The JASPAR database was used to analyse CBSs in YAP promoter sequences (Additional file 3: Fig. S2A). The three candidate sites with the highest predicted score were − 818 to 825 bp, − 2664 to 2671...