This is achieved by simply an extrapolation of the locus of the plot of pKaH of protonated pyridine, pyridazines, s-triazine and 1,2,4,5-tetrazine versus the number of nitrogen atoms of the cyclic azines. Even well matched pKaH values for these two species were found from the ...
Tetracyclines are a class of derivatives of polycyclic naphthacene carboxamide, which have attracted wide interest in the pharmaceutical field for their use as antibiotics. These molecules are characterized by a substantial conformational flexibility and by the presence of different binding sites which endo...
The pKA values of protonated triethylamine, pyridine and 2,2-dipyridyl in propylene carbonate (PC) were determined by applying the coulometric––potentiometric method and a hydrogen/palladium generator anode (H2/Pd). The investigated and reference base were titrated to 50 % with protons ...
Equation (1) relies on the definition of ΔG’a,sol(AH/BH+), which stands for the reduced basicity of base A− or B in solution and equals difference in the Gibbs energies of the neutral and protonated forms of the acid/conjugate base pair. Gsol(H+) is the Gibbs energy of the ...