Perturbation of the NH 2 pKa value of adenine in platinum(II) complexes: Distinct stereochemical internucleobase effects. Chem Eur J. 2004; 10 :1046–1057.Anorbe, Perturbation of the NH2 pKa Value of Adenine in Platinum(II) Complexes: Distinct Stereochemical Internucleobase Effects; Chem. Eur....
These splice variants share a similar 525-amino acid NH2-terminal core, but diverge significantly at their C-termini [63]. AKAP84 and AKAP121 interact with the OMM via β-tubulin to tether PKA to the cytoplasmic surface of mitochondria [64]. AKAP121 is also involved in the transport of ...
The properties of α-amino acids are complex, yet simplistic in that every molecule of an amino acid involves two functional groups: carboxyl (-COOH) and amino (-NH2). Each molecule can contain a side chain or R group, e.g. Alanine is an example of standard amino acid containing methyl ...
However, xib1significantly shifted theVhalfof inactivation of Nav1.2 (− 45.9 ± 0.2 mV to − 55.5 ± 0.2 mV) and theVhalfof activation of Nav1.5 (− 29.3 ± 0.1 mV to − 23.5 ± 0.1 mV). Additionally, Xib13significantly shifted theVhalfof i...
If a drug has a pK_a of 6.7, at what pH will 55% of the drug be in its acidic form? Rank the given compounds based on their relative acidities. strongest acid weakest acid H20, H3CNH2, H3CCH3, H2C-CH2, HCSCH A weak acid (HA) has a pKa value of 4.50. a) At what pH is...
The pKa of acetamide (CH3CONH2) is 16. Draw the structure of its conjugate base and explain why acetamide is less acidic than CH3COOH. What does the pK_a really tell you about the strength of the acid...
(GSTP1), an enzyme for carcinogen and drug metabolism, and c-Jun NH2-terminal kinase signaling [190]. Phosphorylation of GSTP1 at Ser-184 enhances its enzymatic activity and thereby promotes drug resistance in glioblastoma cells [190]. In addition, PGE2-induced cAMP signaling promotes ...
pKa
The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede Xibalbanus tulumensis, an underwater cave-dwelling crustacean, is the only crustacean for whic
the eleventh group is not in a carbon atom when it exists; group G is selected from nr2r3, CN and oh; group M and N are 0 or 1 respectively, but the sum of M + n is 1 or 2, and if the members of rings adjacent to E ring are group e, group M or n are 0 respectively....