PKA, as a key serine/threonine kinase and central element of cellular signal transduction, is extensively expressed across multiple brain regions. The high level of PKA expression is detected in the hippocampus and neocortex3,4,5. Importantly, PKA function is essentially involved in the regulation ...
The pKa of an acid is a constant associated with how much the acid ionizes in solution. pKa is a combination of the p in pH, which stands for power of hydrogen, and the dissociation constant for acids, represented by Ka. Since strong acids, by definition, ionize completely, pKa is more...
pKa数据表
When in pKa calculations with continuum methods, the internal water molecules were treated explicitly, and allowed to relax in the field of the buried charged group, the pKa values of buried residues were reproduced with ϵin in the range 4–5. The calculations show that internal waters can ...
pka无机酸有机酸含氧ripindmso D.H.Ripin,D.A.Evans*Values<0forH2OandDMSO,andvalues>14forwaterand>35forDMSOwereextrapolatedusingvariousmethods.0.79SULFINIC&SULFONICACIDSPEROXIDESH2OpKa(DMSO)(DMSO)pKaH2OH2OpKa(DMSO)pKa'sofInorganicandOxo-Acids8.211.5CH3CO3HMeOOH12.515.5415.7(11.1)(12.3)(1.6)(0.3)...
(27.9) N+ -12.4 H S 7.00 X= CH3 4.76 (12.3) i-PrOH 16.5 (29.3) Ph + OH 2 CH2NO2 1.68 OH HBr -9.00 (0.9) CH F 2.66 t-BuOH 17 (29.4) -7.8 2 HCl -8.0 (1.8) CH2Cl 2.86 c-hex3COH 24 Ph +OHOH CH2Br 2.86 CF CH OH 12.5 (23.5) -6.2 HF 3.17 (15) CH2I 3.12 3 ...
A graphical approach yielded an uncorrected pKa value of 11.07. Degradation of the compound in water, 0.1 M HCl, 0.1 M NaOH and 3% hydrogen peroxide followed a first order reaction. With proper temperature control and maintenance of uniform ionic strength, a reproducible pKa of cryptolepine is ...
Mice lacking the RIIβ regulatory subunit of cyclic AMP-dependent protein kinase A (PKA) display reduced adiposity and resistance to diet-induced obesity. Here we show that RIIβ knockout (KO) mice have enhanced sensitivity to leptin’s effects on both f
Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor. Dibutyryl-cAMP (Bucladesine) Chemical Structure CAS No. 16980-89-5 Purity & Quality Control Batch: Purity...
Cadmium, a heavy metal with wide occurrence in nature has extensive industrial and anthropogenic uses because of its non-corrosive nature and thus enhances the risk of human exposure. Presence of high cadmium levels in cigarette smoke and drinking water are potential sources of non-occupational expos...