An electrochemical technique wasused to investigate pKavalues of somesubstituted secondary alicyclic (SA)amines, pyridines (py), anilines (AN), and triethylamine (Et3N) in different ionic liquids. The method involves cyclic voltammetryat a platinized Pt electrode. The experimental data were correlated...
Part 2: Application to amines, anilines and various nitrogen containing heterocyclic compounds. Quant Struct Act Rel, 2002, 21: 473–485 51 Yu H Y, Kühne R, Ebert R U, et al. Prediction of the dissociation constant pKa of organic acids from local molecular parameters of their electronic ...
The ristocetinisoelectric pointis reached at pH 7.6. Full density functional theory computation gives the following results: two positive charges present on the two primary amines, 0.81 and 0.68 negative charges (1.49 total negative charge) are respectively due to the pKa 7 and pKa 7.3 of the ...
aThe efforts include two chemical approaches: 1) increase the number of reactive nitrogens on the PEI crosslinker by nitrogen deprotonation by the addition of basic amines and 2) replace lower-molecular-weight base polymer with small amounts of high-molecular-weight acrylamide homopolymer. The ...
On the elemental electronegative,bondid electron number and pz eletron number of atoms,one new molecular topological index (4X) is developed for research on the Pka values for 21 substituted phenols and the Pkb values for 22 substituted benzenne amines in this paper. 结果表明,4X具有良好的结构...
MAE Number of training samples Method 5 10 15 20 (f) Amines (tasks Bb, Bc, Bd), median ± median absolute deviation. MAE Number of training samples Method 5 10 15 20 Bb Null 0.81 ±0.17 0.73 ±0.14 0.71 ±0.22 0.75 ± 0.49 STL 0.98 ±0.45 0.81 ±0.18 0.76 ±0.23 0.73 ± ...
The pendant polycationic sidechains of ADA are also expected to electrostatically interact with the anionic phosphate backbones of siRNA33–35. A ternary CB[6]‒ADA‒HACD complex that benefited from the bimodal binding of ADA with two different types of mac- rocycles and was able to...
All else being equal, we should expect that the reaction will favor the formation of theweaker base. 9. Summary If you have a pKatable, you essentially have a ranking of the stabilities of different molecules. (The stronger the base, the more unstable it is). ...
The performance of the most common and also some other less common CE buffers has been tested for the p K a determination of several types of compounds (pyridine, amines, and phenols). The selected buffers cover a pH ranging from 3.7 to 11.8. Whereas some buffers, like acetic acid/acetate...
Under certain conditions, thiocarbamidines (such as No. 990) are unstable towards nucleophiles such as amines, forming thiols and guanidines which can also be used for the treatment of diseases, for example. In a preferred embodiment, the invention therefore relates to the cyclic imidazoles (6...