Amino acids are a crucial, yet basic unit of protein, and they contain an amino group and a carboxylic group. They play an extensive role in gene expression process, which includes an adjustment of protein functions that facilitate messenger RNA (mRNA) translation. There are over 700 types of...
第22卷第1期1996年1月曲阜师范大学学报JournalofQufuNormalUniversityVol.22No.1Jan.1996氨基酸的等电点与pKa的关系Ξ刘崇凤付彩霞(滨州医学院化学教研室,256603,山东省滨州市)摘要根据氨基酸的电离平衡,讨论了碱性和酸性氨基酸的等电点与pKa的关系,得到氨基酸的等电点的计算公式。关键词电离平衡等电点氨基酸分类号O...
氨基酸的等电点与pKa的关系
Table 10lists pKavalues of severalDTTsbearing acidic or basic groups.DTT5-carboxylic acids (e.g.64) are rather strong acids, comparable todichloroacetic acid(98J(P2)387); in the case of the less-acidic 4-carboxylic acid (89a), analkyl groupin the 5-position unexpectedly lowers the pKavalu...
Answer to: Explain each statement. a) The pKa of p-nitrophenol is lower than the pKa of phenol (7.2 vs. 10). b) The pKa of p-nitrophenol is lower...
% at fixed 25C潞 temperature on the values of ionization constants pKa for some acidic and basic imines . These imines are derived 3-acetyl and 4-acetyl pyridines in a forms of syn or anti oxime and phenolic or amino Schiff bases , containing phenol and primary amine groups in ortho , ...
Conversely, acidity in the haloacids increases as we movedownthe column. In order to make sense of this trend, we will once again consider the stability of the conjugate bases. Because fluorine is the most electronegative halogen element, we might expect fluoride to also be the least basic hal...
The two variants of the α-form of the catalytic (C) subunit of protein kinase A (PKA), designated Cα1 and Cα2, are encoded by the PRKACA gene. Whereas Cα1 is ubiquitous, Cα2 expression is restricted to the sperm cell. Cα1 and Cα2 are encoded with
One of the most important physicochemical properties of small molecules and macromolecules are the dissociation constants for any weakly acidic or basic groups, generally expressed as the pK(a) of each group. This is a major factor in the pharmacokinetics of drugs and in the interactions of protei...
2c) bound with high nanomolar affinity to purified PKAC in the presence of the non-hydrolysable ATP analogue adenylyl-imidodiphosphate (Fig. 2h; Supplementary Fig. 2g,h). A similar value was obtained with a PKI-derived peptide (amino acids 5-24), supporting our notion of related binding ...