The evidence for the postulation of acyl-enzyme intermediates in 伪-hymotrypsin-catalyzed hydrolysis of specific ester, acid, and amide substrates is summarized. Individual rate constants determined from relative rate data, the effect of... ML Bender,FJ Kezdy - 《J.am.chem.soc》 被引量: 291...
In the case of creatine kinase, the hydrogen bond donors are a serine side chain and an amide NH-group, while in alpha1-antitrypsin the donor is an amide NH. Each hydrogen bond lowers the pK(a) by between 0.8 and 1.5 pH units. The 1.1-unit lowering due to the Ser284-Cys282 ...
The terminal amino 15N data were collected using a two-dimensional ver- sion of the HACAN pulse sequence30, essentially in the form of Kanelis et al.31, modified to provide discrimina- tion against the unwanted signals from backbone amide groups and side-chain amino groups of lysine ...
3A). The hydroxyl group of the Thr-73 side chain participates in a helix-capping interaction with the main-chain amide group of Glu-76 at the N terminus of helix αB in the “N” SH2 domain. Similarly, the hydroxyl group of the Ser-189 side chain forms a helix cap with the main-...
If an amide group is protonated, it will be at the oxygen rather than the nitrogen. Exercises 1. a) Draw the Lewis structure of nitric acid, HNO3. b) Nitric acid is a strong acid – it has a pKaof -1.4. Make a structural argument to account for its strength. Your answer should in...
In the case of creatine kinase, the hydrogen bond donors are a serine side chain and an amide NH-group, while in alpha1-antitrypsin the donor is an amide NH. Each hydrogen bond lowers the pK(a) by between 0.8 and 1.5 pH units. The 1.1-unit lowering due to the Ser284-Cys282 ...
Question: Rank from best acid (low pKa) to worse acid (high pKa). Acid: Acids are the substance that can provide {eq}{{\rm{H}}^{\rm{ + }}} {/eq} ions or receive an electron pair. The reactivity of the conjugate base shares an inverse relation with acid's strength. Lower the...
Temporal lobe epilepsy (TLE) is one of the most common and intractable neurological disorders in adults. Dysfunctional PKA signaling is causally linked to the TLE. However, the mechanism underlying PKA involves in epileptogenesis is still poorly understo
management. This study evaluated the effectiveness of INT-B compared with that of traditional constant energy constraint (CER) for increasing human body structure and attenuating metabolic version. Random-effects meta-analyses were performed for within-group and between-group comparisons of anthropometric ...
pKa