In the case of creatine kinase, the hydrogen bond donors are a serine side chain and an amide NH-group, while in alpha1-antitrypsin the donor is an amide NH. Each hydrogen bond lowers the pK(a) by between 0.8 an
The terminal amino 15N data were collected using a two-dimensional ver- sion of the HACAN pulse sequence30, essentially in the form of Kanelis et al.31, modified to provide discrimina- tion against the unwanted signals from backbone amide groups and side-chain amino groups of lysine ...
cAMP-elevating agents, such as forskolin, can not only induce cancer cell death, but also directly inhibit cell proliferation in some cancer types. In this review, we summarize current understanding of cAMP signaling in cancer biology and immunology and discuss the basis for its context...
In the case of creatine kinase, the hydrogen bond donors are a serine side chain and an amide NH-group, while in alpha1-antitrypsin the donor is an amide NH. Each hydrogen bond lowers the pK(a) by between 0.8 and 1.5 pH units. The 1.1-unit lowering due to the Ser284-Cys282 ...
pKa
Amide hydrogen atoms were exchanged by increasing the temperature to the midpoint temperature for 15 min followed by centrifugation. A total volume of at least 1.2 ml was prepared at pH 8.0, and this sample was split into two fractions, one for titration with acid and one for titration with...
3A). The hydroxyl group of the Thr-73 side chain participates in a helix-capping interaction with the main-chain amide group of Glu-76 at the N terminus of helix αB in the “N” SH2 domain. Similarly, the hydroxyl group of the Ser-189 side chain forms a helix cap with the main-...
Temporal lobe epilepsy (TLE) is one of the most common and intractable neurological disorders in adults. Dysfunctional PKA signaling is causally linked to the TLE. However, the mechanism underlying PKA involves in epileptogenesis is still poorly understo
Synthesis Strategies of benzene 11個詞語 DaraK_23 預覽 這個學習集的練習題 學習 1 / 7 用學習模式學習 25 選擇正確的詞語 1 carboxylic acid 2 alkyne 3 hydronium 4 ester 不知道嗎? 本學習集中的詞語(21) carboxylic acid 5 nitrile 10 alcohol 15 ketone 20 alkyne 25 amide 25 amine 35 ester 25...
(5-24)amide; PKI(5-22)amide; PKI-(6-22)- amide; PKI(14-22)amide; PKI(14-24)amide; Malantide Pan-EPAC ESI-08; ESI-09; HJC0197 EPAC1 AM-001; CE3F4; EPAC 5376753 EPAC2 AAK-399; AAD-026; MAY0132; HJC0350 Forskolin 6-Bnz-cAMP; 8-Bromo-cAMP; Sp-cAMPS; CW 008; Bucla...