The differences may be explained by different temperature, ionic strength and analytical methods used. The accuracy of the method employed in this work was checked by phosphoric acid titrations. As mentioned before, a ±0.2 pKa value deviation may be expected in our results. Table 2. Macroscopic...
For oxygen containing organic compounds this is given: pKa (the negative logarithm of the acid dissociation constant), molecular structures, molar weights, density and melting and boiling points.
pKa - The pKa value is the negative base -10 logarithm of the acid dissociation constant (Ka) of a solution. The quantitative behavior of acids and bases in solution can be understood only if their pKa values are known. To learn more about Calculation o
The pK of acetic acid (CH3CO2H) is 4.8. Explain why the carboxylic acid group of Amoxicillin (pK=2.4), a synthetic penicillin, is more acidic than acetic acid, whereas the carboxylic acid group of indomethacin (pKa= 4.5), an anti-inflammatory analgesic used to treat rheumatoid arthritis, ...
A simple example is hydrochloric acid, in which the one and only covalent bond is H-Cl. Such bonds are reversibly dissociated after the acid is dissolved into aqueous solution. This always forms hydrogen ion and conjugate base products. If the solution system is closed and ...
The results of CS were consistent with that of pKa values on both the yield of XOS and the inhibitor. Conclusion The results based on pKa values and combined severity, a parameter associated with temperature and reaction time, concluded that acetic acid is a preferred catalyst. Combining the ...
ADA was prepared in 4 steps from adamantyl bromomethyl ketone (2) and the pentafluorophenyl ester of Cbz-protected 4-ami- nobutylaminoacetic acid (6) (see Supplementary Figs S1−S18). As illustrated in Fig. 1, ADA carries two types of independent guest moieties. One is the bulky ...
Ssanghwa-tang (SHT) is a widely used medication for the treatment of fatigue, pain, inflammation, hypothermia, erectile dysfunction, cancer, and osteoporosis in Asia, however, role of SHT on the melanin synthesis has not been checked previously. Thus, the present study was designed to determine...
💡 Unlike pH, Ka does not vary with the concentration, but it does vary with temperature changes. That means Ka values of acids are usually fixed. Acid dissociation equation This equation explains the dissociation of an acid at equilibrium, giving hydronium ions (H+) and conjugate base (A-...
The library consisted of 72 potential CDK substrates that matched the CDK consensus motif along with 102 controls that either had no fold change in the phosphoproteomics data and no discernable motif or were substrates of a different kinase with a −3R preference. All 174 test substrates were ...