H89 2HCl是一种有效的PKA抑制剂,Ki为48 nM,作用于PKA比作用于PKG选择性高10倍,比作用于PKC,MLCK,钙调蛋白激酶II和酪蛋白激I/II选择性高500倍。 化学名 (E)-N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride CAS号 130964-39-5 分子式 C20H20BrN3O2S·2HCl 分子量 519.28 ...
PKA inhibitor H89 prevents the SKF38393-dependent enhancement of NK cell cytotoxicity.Wei ZhaoYan HuangZhan LiuBeiBei CaoYuPing PengYiHua Qiu
PKA inhibitor H89 inhibits ET-1- and isoprenaline-induced ATF3 increase in NRCM.Elina KoivistoAlicia Jurado AcostaAnneMari MoilanenHeikki TokolaJani AroHarri PennanenHanna SäkkinenLeena KaikkonenHeikki RuskoahoJaana Rysä
4.Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89: N.H. Ashour, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry111, 110366 (2021) 5.Role o...
4.Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89: N.H. Ashour, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 111, 110366 (2021)5.Role ...
4.Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89: N.H. Ashour, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry111, 110366 (2021) ...
4.Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89: N.H. Ashour, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry111, 110366 (2021) ...
4.Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89: N.H. Ashour, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry111, 110366 (2021) ...
(E)-N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride; H 89 2HCl;H-89 dihydrochloride; H89 Dihydrochloride; H 89;Protein kinase inhibitor H-89 dihydrochloride 中文名称(Chinese Name) H-89双盐酸盐 靶点(Target)
The specific inhibitor of PKA, H89, decreased progesterone synthesis in mitochondria while in mitochondrial steroidogenic contact sites protein-phosphorylation was diminished, suggesting that PKA plays a role in placental hormone synthesis. In isolated mitochondria, PKA activity was unaffected by the ...