(2003) PKA and MAPK Phosphorylation of Prf1 Allows Promoter Discrimination in Ustilago maydis. EMBO Journal, 22, 5817-5826. http://dx.doi.org/10.1093/emboj/cdg554Kaffarnik F,Muller P,Leibundgut M,Kahmann R,Feldbrugge M. PKA and MAPK phosphorylation of Prf1 allows promoter discrimination in ...
裂原活化蛋白激酶(MAPK)信号转导通路的激活。为了探索免疫调变过程中其他信号对MAPK通路的影响,以 LPS调变小鼠腹腔抑制性巨噬细胞为模型,研究了cAMP/PKA和佛波酯(PMA)/PKC信号对MAPK家族成员 p44/p42(胞外调控激酶1/2,extracellularregulatedkinase1/2,ERK1/2)、c2JunN端激酶(JNK)和p38的调节作用。
Since cAMP signaling regulates cell proliferation and differentiation, abnormal cAMP biogenesis is involved in tumorigenesis, a complex disease resulting from diverse environmental and genetic factors [11]. cAMP has a significant impact on both cancer cells and the tumor microenvironment (TME). Cytokines,...
Both PKA/MITF and MAPK/MITF signaling pathways were found to be involved in the suppression of melanogenesis by glabridin in B16 cells. Also in vivo glabridin therapy significantly reduced hyperpigmentation, epidermal thickening, roughness and inflammation induced by frequent UVA exposure in mice skins,...
Condition-specific genetic interaction maps reveal crosstalk between the cAMP/PKA and the HOG MAPK pathways in the activation of the general stress response Mol. Syst. Biol., 11 (2015), p. 829 View in ScopusGoogle Scholar 55 E.A. First, J. Bubis, S.S. Taylor Subunit interaction sites be...
The ERK cascade: a prototype of MAPK signaling. Mol Biotechnol. 2005;31(2):151–74. Article CAS PubMed Google Scholar Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci. 2006;31(5):268–75.Available from: https://www.cell.com/trends...
p38 MAPK PKA PKB / AKT Drug Development ADME Lead Optimisation Target Validation Immune Response Thermodynamic Analysis Concentration Analysis Further Applications Techniques Biacore Biacore T200 Products Recombinant Kinases Kinase Inhibitors Kinase Substrates ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook PKA Dictionary Medical Acronyms Wikipedia PKA [¦pē¦kā′ā] (cell and molecular biology) cyclic AMP-dependent protein kinase (physics) primary knocked-on atom ...
Overall, p38 MAPK might regulate multiple functions in A. amphitrite cyprids, including the energy supply, metamorphosis, neural system and cement glands. 展开 关键词: MITOGEN-activated protein kinases SERINE proteinases CYPRIDIDAE PROTEOMICS PROTEIN expression DOWNREGULATION ...
肺水肿和炎症损伤主要与VIP/cAMP/PKA信号轴的激活有关;因此,联合治疗将恢复AQP-1和AQP-5蛋白的表达,抑制NF-κB和MAPK信号通路,抑制M1巨噬细胞的极化,促进M2巨噬细胞的极化。此研究综合评价了联合治疗对这些相关因素的影响,结果为伪麻黄碱联合大黄素治疗ALI提供了有...